Results 191 to 200 of about 29,245 (221)

Induction of diplochromosomes in mammalian cells by inhibitors of topoisomerase II

Chromosoma, 1998
Diplochromosomes, consisting of four chromatids lying side-by-side, instead of the normal two, are produced when cells go through two rounds of DNA replication without separation of chromatids. They are thus an indication of the failure of the normal chromosome separation mechanism.
openaire   +2 more sources

Genotoxicity of topoisomerase II inhibitors: An anti-infective perspective

Toxicology, 2008
At present, an inevitable consequence of a chemical's inhibitory activity on key regulators of DNA topology in bacteria, the type II topoisomerases, is a less pronounced effect on their eukaryotic counterparts. In the context of anti-infectives drug development, this may pose a risk to patient safety as inhibition of eukaryotic type II topoisomerases ...
openaire   +2 more sources

[Molecular determinants of response to topoisomerase I inhibitors].

Bulletin du cancer, 2011
Nuclear topoisomerase I (Top1) is involved in the relaxation of DNA supercoiling and plays a pivotal role in the coordination of essential DNA processes such as transcription, replication, DNA recombination and DNA damage signalling. For all these reasons, Top1 has been an attractive target for the development of anticancer drugs, which poison Top1 by ...
Pourquier, Philippe, Lansiaux, Amélie
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Topoisomerase II inhibitors

2005
Danko, Martincic, Kenneth R, Hande
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A patent review of topoisomerase I inhibitors (2016–present)

Expert Opinion on Therapeutic Patents, 2021
Asier Selas, Endika Martin-Encinas, Maria Fuertes   +2 more
exaly  

DNA topoisomerase: the mechanism of resistance to DNA topoisomerase II inhibitor VP-16. [PDF]

Hiroshima journal of medical sciences, 1990
K6-1 and 50B-3 cell lines, resistant to VP-16, a DNA topoisomerase II inhibitor, were established from two different types of cells respectively: human T-cell derived acute lymphoblastic leukemia cell line RPMI8402 and mouse mammary tumor cell line FM3A.
openaire   +1 more source

DNA Topoisomerase II Inhibitors

2021
openaire   +1 more source

The design and discovery of topoisomerase I inhibitors as anticancer therapies

Expert Opinion on Drug Discovery, 2022
Endika Martin-Encinas, Asier Selas, FRANCISCO Palacios   +2 more
exaly  

Topoisomerase II inhibitors

Drug Discovery Today, 1996
openaire   +1 more source

Recent advancements in the medicinal chemistry of bacterial type II topoisomerase inhibitors

Bioorganic Chemistry, 2020
Shalini Jaswal, Vikramdeep Monga
exaly