Results 21 to 30 of about 29,245 (221)
Hyperthermia, thermotolerance and topoisomerase II inhibitors [PDF]
British Journal of Cancer, 1995 The cytoxicity of both intercalating (m-AMSA) and non-intercalating (VP16, VM26) topoisomerase II-targeting drugs is thought to occur via trapping DNA topoisomerase II on DNA in the form of cleavable complexes. First, analysis of cleavable complexes (detected as DNA double-strand breaks) by pulsed-field gel electrophoresis confirmed the correlation ...
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Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening.
PLoS ONE, 2014 DNA topoisomerases are enzymes responsible for the relaxation of DNA torsional strain, as well as for the untangling of DNA duplexes after replication, and are important cancer drug targets.
Malgorzata N Drwal +5 more
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TOPOISOMERASE II ENZYME INHIBITORS
Ankara Universitesi Eczacilik Fakultesi Dergisi, 2020 Amaç: Son yıllarda önemi daha da artan topoizomeraz II enzim inhibitörleri’nin Farmasötik Kimya bilimi açısından ve klinik kullanımları değerlendirilmiştir. Bu bağlamda, klinik kullanımları olan bileşiklerin yanında geliştirilme aşamasında olan bazı bileşiklere de yer verilmiştir.Sonuç ve Tartışma: Topoizomeraz II enzimi inhibisyonu hedefli kanser ...
FIRAT, Oğuzhan, YILDIZ, İlkay
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Cadmium is a catalytic inhibitor of DNA topoisomerase II [PDF]
Journal of Inorganic Biochemistry, 2011 Cadmium (Cd(2+)) is a highly toxic and carcinogenic metal that is an environmental and occupational hazard. DNA topoisomerase II is an essential nuclear enzyme and its inhibition can result in the formation of genotoxic and recombinogenic DNA double strand breaks.
Xing, Wu +2 more
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Dual role of topoisomerase II in centromere resolution and aurora B activity.
PLoS Biology, 2008 Chromosome segregation requires sister chromatid resolution. Condensins are essential for this process since they organize an axial structure where topoisomerase II can work. How sister chromatid separation is coordinated with chromosome condensation and
Paula A Coelho +5 more
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Resveratrol: A novel type of topoisomerase II inhibitor [PDF]
Journal of Biological Chemistry, 2017 Resveratrol, a polyphenol found in various plant sources, has gained attention as a possible agent responsible for the purported health benefits of certain foods, such as red wine. Despite annual multi-million dollar market sales as a nutriceutical, there is little consensus about the physiological roles of resveratrol.
Joyce H, Lee +2 more
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Assessing Sensitivity to Antibacterial Topoisomerase II Inhibitors [PDF]
Current Protocols in Pharmacology, 2007 AbstractBoth prokaryotes and eukaryotes have two major classes of topoisomerases that make transient single‐ or double‐strand cuts in DNA. While these enzymes play critical roles in cellular processes, they are also important targets of therapeutic agents.
Sonia K, Morgan-Linnell +3 more
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Frontiers in Oncology, 2022 Topoisomerases, targets of inhibitors used in chemotherapy, induce DNA breaks accumulation leading to cancer cell death. A newly synthesized copper(II) indenoisoquinoline complex WN197 exhibits a cytotoxic effect below 0.5 µM, on MDA-MB-231, HeLa, and HT-
Caroline Molinaro +6 more
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Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents
Molecules, 2019 To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors.
Ming-Jie Chu +8 more
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Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor. [PDF]
PLoS ONE, 2013 Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell death.
Bokun Cheng +6 more
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