Results 251 to 258 of about 4,050,496 (258)

Topoisomerase inhibitors: pharmacology and emerging nanoscale delivery systems.

Pharmacological Research, 2019
Topoisomerase enzymes have shown unique roles in replication and transcription. These enzymes which were initially found in Escherichia coli have attracted considerable attention as target molecules for cancer therapy.
A. Dehshahri, M. Ashrafizadeh, E. Afshar, A. Pardakhty, Ali Mandegary, R. Mohammadinejad, G. Sethi   +6 more
semanticscholar   +1 more source

Topoisomerase Inhibitors and Targeted Delivery in Cancer Therapy.

Current Topics in Medicinal Chemistry, 2019
DNA topoisomerases are enzymes that catalyze the alteration of DNA topology with transiently induced DNA strand breakage, essential for DNA replication. Topoisomerases are validated cancer chemotherapy targets. Anticancer agents targeting Topoisomerase I
Fei You, Changshou Gao
semanticscholar   +1 more source

ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents

Expert Opinion on Therapeutic Patents, 2019
Introduction: The bacterial topoisomerases DNA gyrase and topoisomerase IV are validated targets for development of novel antibacterial agents. Fluoroquinolones inhibit the catalytic GyrA and/or ParC(GrlA) subunit and have been commonly used, although ...
Martina Durcik, T. Tomašič, Nace Zidar, A. Zega, D. Kikelj, L. P. Mašič, J. Ilaš   +6 more
semanticscholar   +1 more source

Topoisomerase II inhibitors in AML: past, present, and future

Expert Opinion on Pharmacotherapy, 2019
Introduction: Topoisomerase II inhibitors have long been used in the frontline and as salvage therapy for AML, with daunorubicin and idarubicin being prototypical agents in this therapeutic class, classically in combination with nucleoside analogs, e.g ...
M. Economides, Deborah McCue, G. Borthakur, N. Pemmaraju   +3 more
semanticscholar   +1 more source

Panobinostat induces apoptosis via production of reactive oxygen species and synergizes with topoisomerase inhibitors in cervical cancer cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016
Lubna Wasim, Madhu Chopra
semanticscholar   +1 more source

Discovery and Development of Topoisomerase Inhibitors as Anticancer Agents.

Mini-Reviews in Medical Chemistry, 2016
M. Kathiravan, A. Kale, Shrikant S. Nilewar   +2 more
semanticscholar   +1 more source

Topoisomerase I inhibitors: camptothecins and beyond

Nature Reviews. Cancer, 2006
Y. Pommier
semanticscholar   +1 more source

Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors.

European journal of medicinal chemistry, 2018
M. Sathish, B. Kavitha, V. L. Nayak, Yellaiah Tangella, Ayyappan Ajitha, Shalini Nekkanti, A. Alarifi, N. Shankaraiah, N. Nagesh, A. Kamal   +9 more
semanticscholar   +1 more source