Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.ABSTRACT Doxorubicin (DOX) and cyclophosphamide (CP) are widely used chemotherapeutic agents with known gonadotoxic effects. Since miRNAs play a key role in the transcriptional regulation of spermatogenesis, they are suggested as biomarkers for male infertility.
Hülya Öztatlıcı +4 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó +14 more
wiley +1 more source
Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications
International Journal of Laboratory Hematology, Volume 48, Issue 5, Page 961-971, October 2026.ABSTRACT Clonal hematopoiesis (CH) is increasingly recognized as a significant biological phenomenon in aging and cancer, marked by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations in genes associated with myeloid neoplasms.
Wei Du +4 more
wiley +1 more source
Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release
Chemistry – A European Journal, Volume 32, Issue 35, 19 September 2026.Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka +6 more
wiley +1 more source
The evolving role of immunotherapy in ovarian cancer
Cancer, Volume 132, Issue 18, 15 September 2026.Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani +2 more
wiley +1 more source
Clinical management of clonal hematopoiesis
Cancer, Volume 132, Issue 18, 15 September 2026.ABSTRACT Clonal hematopoiesis, particularly clonal hematopoiesis of indeterminate potential and clonal cytopenia of undetermined significance, is an age‐related premalignant condition characterized by the expansion of hematopoietic clones carrying somatic mutations.
Kelly S. Chien +1 more
wiley +1 more source
Quinoline-Based Scaffolds in Anticancer Drug Discovery: Molecular Targets, Synthetic Strategies, and Biological Advances. [PDF]
ChemMedChemRaza A, Wadhwa P, Sharma S.
europepmc +1 more source
HER2-Targeted Antibody-Drug Conjugates in Advanced HER2-Low Breast Cancer: Mechanisms, Clinical Efficacy, and Resistance Strategies. [PDF]
Cancer Manag ResYang M, Ding X, Ye P, Xu X.
europepmc +1 more source
Chemotherapy is associated with faster abdominal aortic aneurysm growth in patients with concomitant cancer in a multicenter cohort. [PDF]
Clinics (Sao Paulo)Kumakura HS +7 more
europepmc +1 more source
Identification of Repurposed Drugs Against Monkeypox Virus Through Comprehensive Virtual Screening. [PDF]
Biotechnol JYu T, Jang WD, Lee SY.
europepmc +1 more source