Results 31 to 40 of about 4,050,496 (258)

Topoisomerase I inhibitors: Challenges, progress and the road ahead.

European journal of medicinal chemistry, 2022
Topoisomerase IB (Top1), a subcategory of DNA topoisomerase enzymes is expressed much higher in several tumor cells. Therefore, modulating the activity of Top1 in tumor cells to prevent DNA replication and subsequent cell division made it an important ...
A. Talukdar, Biswajit Kundu, Dipayan Sarkar, Sunny Goon, M. Mondal   +4 more
semanticscholar   +1 more source

Recent developments in topoisomerase-targeted cancer chemotherapy

Acta Pharmaceutica Sinica B, 2018
The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously in all domains of life. The various topoisomerase enzymes perform a wide range of functions related to the maintenance of DNA topology during DNA replication, and ...
KirkE. Hevener, Tatsiana A. Verstak, Katie E. Lutat, Daniel L. Riggsbee, Jeremiah W. Mooney   +4 more
doaj   +1 more source

Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold [PDF]

, 2019
A new class of topoisomerase I inhibitors containing the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one (abbreviated as BBPI) ring system have been developed based on structure-activity relationship studies of the cytotoxic marine alkaloid ...
Iwao, Masatomo, Fujimoto, Masahiro, Ishibashi, Fumito, Okazaki, Fumiyasu, Nanjo, Yusuke, Yoshida, Kenyu, Fukuda, Tsutomu, Natsui, Yuko, To, Hideto   +8 more
core   +1 more source

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity

Química Nova, 2012
Seven natural neolignans isolated from Licaria chrysophylla and Licaria aurea along with five semisynthetic derivatives were tested for their inhibitory action on DNA-topoisomerase by relaxation assays on pBR322 plasmid DNA.
Amanda de Melo Bezerra, Antônio Cláudio da Silva Lins, Petrônio Filgueiras de Athayde-Filho, Marcelo Sobral da Silva, José Maria Barbosa-Filho, Celso Amorim Camara, Tania Maria Sarmento Silva, Vanessa da Silva Luna, Creusioni Figueredo dos Santos   +8 more
doaj   +1 more source

DNA topoisomerases participate in fragility of the oncogene RET [PDF]

, 2013
Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
Yuh-Hwa Wang (457429), Dillon, LW, Yuh-Hwa Wang, Christine E. Lehman (457427), Laura W Dillon, Dillon Laura W., Nikiforov Yuri E., Pierce Levi C. T., Wang, YH, Laura W. Dillon (457426), Lehman, Christine E., Christine E Lehman, Lehman, CE, Pierce, Levi C. T., Nikiforov, Yuri E., Pierce, LCT, Yuri E. Nikiforov (457428), Levi C T Pierce, Rybenkov, Valentin V, Wang, Yuh-Hwa, Wang Yuh-Hwa, Levi C. T. Pierce (454414), Lehman Christine E., Yuri E Nikiforov, Dillon, Laura W., Nikiforov, YE   +25 more
core   +2 more sources

Marine-Derived Compounds Targeting Topoisomerase II in Cancer Cells: A Review

Marine Drugs, 2022
Cancer affects more than 19 million people and is the second leading cause of death in the world. One of the principal strategies used in cancer therapy is the inhibition of topoisomerase II, involved in the survival of cells.
Giulia Greco, Valentina Pellicioni, Ivan Cruz-Chamorro, Giuseppe Attisani, Claudio Stefanelli, Carmela Fimognari   +5 more
doaj   +1 more source

Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive Staphylococcus aureus.

ACS Medicinal Chemistry Letters, 2020
In recent years, novel bacterial topoisomerase inhibitors (NBTIs) have been developed as future antibacterials for treating multidrug-resistant bacterial infections. A series of dioxane-linked NBTIs with an amide moiety has been synthesized and evaluated.
Yanran Lu, Jonathan L. Papa, S. Nolan, Anthony E. English, Justin T. Seffernick, Nicholas Shkolnikov, Josh Powell, Steffen Lindert, D. Wozniak, J. Yalowich, M. Mitton-Fry   +10 more
semanticscholar   +1 more source

A role for topoisomerase II alpha in chromosome damage in human cell lines [PDF]

, 2010
Human response to ionising radiation (IR) shows a wide variation. This is most clearly seen in the radiation-response of cells as measured by frequencies of chromosomal aberrations.
Terry, Samantha Y.A.
core   +2 more sources

Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor. [PDF]

PLoS ONE, 2013
Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell death.
Bokun Cheng, Shugeng Cao, Victor Vasquez, Thirunavukkarasu Annamalai, Giselle Tamayo-Castillo, Jon Clardy, Yuk-Ching Tse-Dinh   +6 more
doaj   +1 more source

Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks

Cell Reports, 2016
During transcription and DNA replication, the DNA template is overwound ahead of RNA and DNA polymerases and relaxed by DNA topoisomerases. Inhibitors of topoisomerases are potent anti-cancer agents.
Cyril Ribeyre, Ralph Zellweger, Maeva Chauvin, Nicole Bec, Christian Larroque, Massimo Lopes, Angelos Constantinou   +6 more
doaj   +1 more source