Results 131 to 140 of about 67,641 (348)

Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells*

Journal of Biological Chemistry, 2012
Background: Tdp1 is a DNA repair enzyme conserved across eukaryotes. Results: Tdp1 repairs not only 3′-tyrosyl-DNA bonds and 3′-phosphoglycolates but also 5′-tyrosyl-DNA bonds and 3′-deoxyribose phosphates.
J. Murai, Shar-yin N. Huang, B. Das, T. Dexheimer, S. Takeda, Y. Pommier   +5 more
semanticscholar   +1 more source

A pH‐responsive charge‐reversal liposome with enhanced biofilm penetration for multimodal synergistic therapy of bacterial infections

BMEMat, EarlyView.
This study develops a pH‐responsive, charge‐reversal liposome for treating bacterial biofilm infections. With enhanced penetration capability, the liposome effectively delivers antibacterial agents into biofilms. By integrating photodynamic and photothermal therapies with antibiotics, it significantly eradicates biofilms and accelerates bacteria ...
Ruyue Li, Bo Liu, Cheng Wang, Zhencheng Sun, Shuyi Lv, Liang Tian, Minghui Xiao, Qinyang Zheng, Linqi Shi, Chunlei Zhu   +9 more
wiley   +1 more source

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing [PDF]

, 2008
Joseph E. Deweese, Neil Osheroff
openalex   +1 more source

Optimizing Body Size‐Based Dosing Approaches for Antibody–Drug Conjugates

Clinical Pharmacology &Therapeutics, EarlyView.
Optimized dosing precision of antibody–drug conjugates (ADCs) remains challenging due to narrow therapeutic indices, efficacious doses near the maximum tolerated dose, and substantial interindividual variability in exposure. Body size‐based dosing can reduce exposure variability when the allometric scaling exponent for clearance α = 1 but may over‐ or ...
Andrew B. SyBing, Diane D. Wang
wiley   +1 more source

Probabilidades de transición en diagramas de nudos [PDF]

, 2015
Treballs Finals de Grau de Matemàtiques, Facultat de Matemàtiques, Universitat de Barcelona, Any: 2015, Director: Carles CasacubertaSome enzymes like condensins or type II topoisomerases are capable of changing the topology of cyclic DNA molecules.
Orenes Chueca, Pablo
core  

Expression of resistance factors (P-glycoprotein, glutathione S-transferase-π, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas [PDF]

, 1993
M Volm, Michael Kästel, Jürgen Mattern, Thomas Efferth   +3 more
openalex   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Topoisomerase inhibitors suppressed lithocholic acid-induced promotion of transformation in BALB/3T3 [PDF]

, 1987
Motohisa Kaneko, Junko Horikoshi
openalex   +1 more source

IP-MS, MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes

, 2023
Yoshiho Ikeuchi, Azad Bonni, Harrison W. Gabel   +2 more
openalex   +1 more source

Associations Between GLP‐1 Receptor Agonists and Alopecia: A Multi‐Centre Retrospective Analysis and Public Interest Trends

JEADV Clinical Practice, EarlyView.
ABSTRACT Background There is a growing body of literature suggesting that GLP‐1 receptor agonists (GLP‐1RAs) may be associated with hair loss; however, primary literature is sparse. Additionally, it is not well‐established which types of hair loss may be associated with GLP‐1RA use. Objectives This study aims to assess associations between GLP‐1RAs and
Lauren M. Ching, Christopher A. Guirguis, Joe K. Tung   +2 more
wiley   +1 more source