Results 231 to 240 of about 67,641 (348)

DNA damage response pathway is a promising therapeutic target for extrachromosomal DNA-positive tumours. [PDF]

Clin Transl Med
Tian C, Gan H.
europepmc   +1 more source

Identification of prokineticin‐2 as potential pharmacodynamic biomarker for overcoming doxorubicin resistance in multicellular breast cancer spheroids

British Journal of Pharmacology, Volume 183, Issue 3, Page 491-504, February 2026.
Background and purpose Despite advances in immunotherapy, doxorubicin (Dox) chemotherapy is still the irreplaceable first‐line therapy for solid tumours such as breast cancer. However, chemotherapy resistance is the major limiting factor, requiring the use of high doses of Dox to achieve the anti‐tumour actions, often leading to severe side effects ...
Martina Vincenzi, Amin Kremic, Nathalie N. Tscheiller, Po‐Yen Hsu, Michael W. Y. Chan, Roberta Lattanzi, Canan G. Nebigil   +6 more
wiley   +1 more source

Torsion is a dynamic regulator of DNA replication stalling and reactivation. [PDF]

Nat Commun
Jia X, Gao X, Zhang S, Inman JT, Hong Y, Singh A, Rashid F, Berger JM, Patel SS, Wang MD.   +9 more
europepmc   +1 more source

A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I

, 1992
Sidney M. Hecht, David E. Berry, Laurie MacKenzie, Robert Busby, Christopher A. Nasuti   +4 more
openalex   +1 more source

Binding of ATP to human DNA topoisomerase I resulting in an alteration of the conformation of the enzyme [PDF]

, 1999
Hui‐Jye Chen, Jaulang Hwang
openalex   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

Unraveling the Role of Topoisomerase 3β (TOP3B) in mRNA Translation and Human Disease. [PDF]

Wiley Interdiscip Rev RNA
Warrick JE, Kearse MG.
europepmc   +1 more source

Characterization of a prokaryotic topoisomerase I activity in chloroplast extracts of maize [PDF]

, 1983
Siedlecki, Janusz, Weissbach, Arthur, Zimmermann, Wolfgang   +2 more
core  

Overexpression of Human DNA Topoisomerase IIα by Fusion to Enhanced Green Fluorescent Protein

, 1998
Yin-Yuan Mo, Keith Ameiss, William T. Beck   +2 more
openalex   +1 more source

Global diversification of coastal Cafius rove beetles (Coleoptera: Staphylinidae) driven by ocean currents since the early Miocene

Cladistics, Volume 42, Issue 1, Page 79-94, February 2026.
Abstract As our understanding of abiotic factors continues to grow, along with insights into the biological traits of organisms, so too does the sophistication of studies exploring global diversification and spatio‐temporal distribution patterns. The global distribution of coastal Cafius rove beetles, combined with the endemic distribution patterns ...
Kee‐Jeong Ahn, Jeong‐Hun Song
wiley   +1 more source