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DNA supercoiling modulates eukaryotic transcription in a gene-orientation dependent manner
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EcoSal Plus, 2015
DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are two types, I and II, classified according to whether they make transient single- or double-stranded breaks in DNA. Their reactions generally involve the passage of a single- or double-strand segment of DNA through this transient break, stabilized by DNA-protein ...
Natassja G Bush +2 more
semanticscholar +3 more sources
DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are two types, I and II, classified according to whether they make transient single- or double-stranded breaks in DNA. Their reactions generally involve the passage of a single- or double-strand segment of DNA through this transient break, stabilized by DNA-protein ...
Natassja G Bush +2 more
semanticscholar +3 more sources
Current Protocols, 2021
AbstractTopoisomerases are enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of DNA topoisomerases: type I enzymes, which make single‐stranded cuts in DNA, and type II enzymes, which cut and decatenate double‐stranded DNA.
John L, Nitiss +4 more
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AbstractTopoisomerases are enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of DNA topoisomerases: type I enzymes, which make single‐stranded cuts in DNA, and type II enzymes, which cut and decatenate double‐stranded DNA.
John L, Nitiss +4 more
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Current Opinion in Structural Biology, 1995
In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
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In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
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Natural Product as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases.
Current protein and peptide science, 2020Topoisomerases are reported to resolve the topological problem of DNA during several cellular processes such as DNA replication, transcription, recombination, and chromatin remodeling.
Swati Singh +4 more
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Annual Review of Biochemistry, 1981
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
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The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
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Current Opinion in Cell Biology, 1990
DNA topoisomerases play an important role in regulating DNA structure, thus affecting many aspects of chromosome function inside cells. Recent progress in this field raises exciting questions regarding the distinct and critical functions of multiple topoisomerases, and the roles of DNA topoisomerases in the processes of chromosome condensation ...
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DNA topoisomerases play an important role in regulating DNA structure, thus affecting many aspects of chromosome function inside cells. Recent progress in this field raises exciting questions regarding the distinct and critical functions of multiple topoisomerases, and the roles of DNA topoisomerases in the processes of chromosome condensation ...
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Current Protocols in Pharmacology, 1998
AbstractTopoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: the type I enzymes, which make single‐stranded cuts in DNA, and the type II enzymes, which cut and pass double‐stranded DNA.
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AbstractTopoisomerases are nuclear enzymes that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: the type I enzymes, which make single‐stranded cuts in DNA, and the type II enzymes, which cut and pass double‐stranded DNA.
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2018
This chapter discusses single-molecule approaches in the study of topoisomerases. After introducing the problem posed by DNA entanglement, it describes type I and type II topoisomerases, which solve that issue. Single-molecule assays have nailed down the different mechanisms of bacterial and eukaryotic type I topoisomerases.
David Bensimon +4 more
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This chapter discusses single-molecule approaches in the study of topoisomerases. After introducing the problem posed by DNA entanglement, it describes type I and type II topoisomerases, which solve that issue. Single-molecule assays have nailed down the different mechanisms of bacterial and eukaryotic type I topoisomerases.
David Bensimon +4 more
openaire +1 more source