Results 211 to 220 of about 11,397 (250)

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Symptom-level interactions between digital addiction and psychological resources: a large-scale cross-validation study. [PDF]

Front Psychol
Aldemir A.
europepmc   +1 more source

The Third‐Generation Magnetic Super‐Stable Mineralizer: Complete Removal and Separation of Multiple Heavy Metal Pollutants

Advanced Science, EarlyView.
The 3rd‐generation magnetic super‐stable mineralizer M‐MgAl‐700 features a core‐shell structure, strong superparamagnetism, large surface area, and abundant oxygen defects. It achieves exceptional Cd(II) and As(V) mineralization capacities, reducing both pollutants in co‐contaminated water and soil to meet national standards.
Haoran Wang, Menghan Huang, Ruihua Mao, Xiaohan Zhang, Zhaohui Wu, Xiaofeng Pang, Tong Lin, Dongyuan Cui, Sai An, Yu‐Fei Song   +9 more
wiley   +1 more source

Precision Medicine Through Network Language: Integrating Clinical Insight and Data Expertise. [PDF]

Genes (Basel)
Palumbo MC, Farina L, Petti M.
europepmc   +1 more source

One‐Dimensional RuIrTe Nanotubes with Amorphous Surface as a Highly Active and Stable Electrocatalyst Toward Oxygen Evolution Reaction in Acidic Media

Advanced Science, EarlyView.
A rational etching‐induced reconstruction strategy is demonstrated to fabricate one‐dimensional RuIrTe ternary nanotubes with a unique amorphous‐crystalline heterostructure. This hierarchical architecture synergistically optimizes mass transport and electronic configurations, delivering record‐breaking performance in proton exchange membrane water ...
Zhi Liang Zhao, Zhe Zhang, Shaoxuan Yang, Jie Zhang, Qi Wang   +4 more
wiley   +1 more source

Assessing Language Skills in Children Aged 4 to 6 Years with Autism Spectrum Disorder: A Prospective Study. [PDF]

Children (Basel)
Mériaux J, Foin S, El Ahmadi A, Assaiante C, Colé P.   +4 more
europepmc   +1 more source

Cucurbit[8]Uril Achieved Single‐Molecule Chiral Transfer to Supramolecular Circularly Polarized Luminescence

Advanced Science, EarlyView.
A single‐molecule cascade supramolecular system comprising L/D‐FPy, CB[8], and SC4AD serves as an efficient light‐harvesting platform. It facilitates cascade energy transfer and chiral transfer to acceptor dyes. Co‐assembly with a PVA matrix produces a multicolor solid film that exhibits enhanced luminescence dissymmetry factors (glum), enabling ...
Yongxue Li, Jie Wu, Weiheng Zhang, Hengzhi Zhang, Wei‐Lei Zhou, Yu Liu   +5 more
wiley   +1 more source

Network rewiring conserves the topology of drought-impaired food webs. [PDF]

Commun Biol
Ma A, Kratina P, Ledger ME, O'Gorman EJ.
europepmc   +1 more source

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

Advanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin, Zijie Chen, Yurong Li, Meijing Fang, Longji Shen, Yilong Su, Odin Zhang, Qinghan Wang, Qun Su, Jike Wang, Tingjun Hou, Yu Kang   +11 more
wiley   +1 more source

Microbial interaction networks as climate thermometers: redefining temperature sensitivity of aerobic methanotrophy in freshwater ecosystems. [PDF]

NPJ Biodivers
Tang Q, Lu L, Xiao Y, Wang D, Li Z.
europepmc   +1 more source