Results 41 to 50 of about 55,932 (263)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Orden y caos en la traducción creativa (aspectos de coherencia textual)

Estudios de Lingüística, 1999
The main aim of the present article is to approach the problems of stability, prototypicality, reorganization and virtuous self-organization in the text of creative translation from a semantic-topological view.
Juan Pedro Gómez Sánchez
doaj   +1 more source

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez, Alejandro F. Manchón‐Gordón, Antonio Vidal‐Crespo, Rafael Caballero‐Flores, Jhon J. Ipus, Clara F. Conde   +5 more
wiley   +1 more source

Stability of fractional quantum Hall states in disordered photonic systems

New Journal of Physics, 2017
The possibility of realizing fractional quantum Hall liquids in photonic systems has attracted a great deal of interest of late. Unlike electronic systems, interactions in photonic systems must be engineered from nonlinear elements and are thus subject ...
Wade DeGottardi, Mohammad Hafezi
doaj   +1 more source

Microstructure Evolution of a VMnFeCoNi High‐Entropy Alloy After Synthesis, Swaging, and Annealing

Advanced Engineering Materials, EarlyView.
The synthesis and processing (rotary swaging and annealing) of the novel VMnFeCoNi alloy is investigated, alongside the estimation of the grain size effect on hardness. Analysis of a wide grain size range of recrystallized microstructures (12–210 µm) reveals a low annealing twin density.
Aditya Srinivasan Tirunilai, Zeki Ayrildi, Buse Şen, Maik Rajkowski, Mathias Redondo Garcia, Markus Stricker, Guillaume Laplanche   +6 more
wiley   +1 more source

M-Polynomials and Degree-Based Topological Indices of the Crystallographic Structure of Molecules

Biomolecules, 2018
Topological indices are numerical parameters used to study the physical and chemical properties of compounds. In quantitative structure–activity relationship QSARs, topological indices correlate the biological activity of compounds with their ...
Wei Gao, Muhammad Younas, Adeel Farooq, Abid Mahboob, Waqas Nazeer   +4 more
doaj   +1 more source

Molecular Dynamics Studies of Shape Memory Polymers: From Bead–Spring Models to Atomistic Simulations

Advanced Engineering Materials, EarlyView.
Coarse‐grained (left) and atomistic (right) models of the shape memory polymer ESTANE ETE 75DT3 are shown schematically. The two representations bridge molecular detail and mesoscopic description. Both models capture shape memory behavior, linking segmental mobility and conformational relaxation of anisotropic chains to macroscopic recovery, and ...
Fathollah Varnik
wiley   +1 more source

Effect of topological defects on graphene geometry and stability

Nanotechnology, Science and Applications, 2010
Ibolya ZsoldosFaculty of Technology Sciences, Szechenyi Istvan University, Gyor, HungaryAbstract: The effect of two basic topological defects, mitosis and the Stone–Wales defect, is studied in the graphene structure.
Ibolya Zsoldos
doaj  

Topological conditions drive stability in meta-ecosystems

Physical Review Research
On a global level, ecological communities are being perturbed at an unprecedented rate by human activities and environmental instabilities. Yet, we understand little about what factors facilitate or impede long-term persistence of these communities ...
Johannes Nauta, Manlio De Domenico
doaj   +1 more source

A machine learning approach to drawing phase diagrams of topological lasing modes

Communications Physics, 2023
Identifying phases and analyzing the stability of dynamic states are ubiquitous and important problems which appear in various physical systems. Nonetheless, drawing a phase diagram in high-dimensional and large parameter spaces has remained challenging.
Stephan Wong, Jan Olthaus, Thomas K. Bracht, Doris E. Reiter, Sang Soon Oh   +4 more
doaj   +1 more source