Results 51 to 60 of about 166,486,521 (293)

Topological states of quantum matter

Physics, 2008
Electrons in graphene can be described by the relativistic Dirac equation for massless fermions and exhibit a host of unusual properties. The surfaces of certain band insulators—called topological insulators—can be described in a similar way, leading to an exotic metallic surface on an otherwise ‘ordinary’ insulator.
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Engineering of Chern insulators and circuits of topological edge states [PDF]

, 2019
Impurities embedded in electronic systems induce bound states which under certain circumstances can hybridize and lead to impurity bands. Doping of insulators with impurities has been identified as a promising route toward engineering electronic ...
Van Dalum, Gerwin A.R., Poÿhönen, Kim, Ojanen, Teemu, Fritz, Lars, Minarelli, Emma L.   +4 more
core   +1 more source

On 2-form gauge models of topological phases

Journal of High Energy Physics, 2019
We explore 2-form topological gauge theories in (3+1)d. These theories can be constructed as sigma models with target space the second classifying space B 2 G of the symmetry group G, and they are classified by cohomology classes of B 2 G.
Clement Delcamp, Apoorv Tiwari
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Topological entanglement entropy for torus-knot bipartitions and the Verlinde-like formulas

Journal of High Energy Physics
The topological Rényi and entanglement entropies depend on the bipartition of the manifold and the choice of the ground states. However, these entanglement quantities remain invariant under a coordinate transformation when the bipartition also undergoes ...
Chih-Yu Lo, Po-Yao Chang
doaj   +1 more source

Pin TQFT and Grassmann integral

Journal of High Energy Physics, 2019
We discuss a recipe to produce a lattice construction of fermionic phases of matter on unoriented manifolds. This is performed by extending the construction of spin TQFT via the Grassmann integral proposed by Gaiotto and Kapustin, to the unoriented pin ±
Ryohei Kobayashi
doaj   +1 more source

Factorization and topological states in c=1 matter coupled to 2D gravity [PDF]

Physics Letters B, 1992
Factorization of the $N$-point amplitudes in two-dimensional $c=1$ quantum gravity is understood in terms of short-distance singularities arising from the operator product expansion of vertex operators after the Liouville zero mode integration. Apart from the tachyon states, there are infinitely many topological states contributing to the intermediate ...
N. Sakai, Y. Tanii
openaire   +2 more sources