Results 191 to 200 of about 290,651 (321)

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

open access: yesAdvanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen   +11 more
wiley   +1 more source

U‐Shaped Response of Flowering Time to Low and High Nitrogen via a Transcription Feedback Loop in Rice

open access: yesAdvanced Science, EarlyView.
The “seesaw effect” of Nhd1‐Ghd7 module in regulating flowering time (days to heading in rice) responses to nitrogen (N) via Hd3a/RFT1: deficient‐N (DN) delays flowering via Ghd7‐mediated suppression of Nhd1; moderate‐N (MN) impairs this suppression, enhancing Nhd1 to promote flowering; whereas superior‐N (SN) delays flowering by Nhd1‐activated ...
Shunan Zhang   +12 more
wiley   +1 more source

Fresnel Magnetic Imaging of Ultrasmall Skyrmion Lattices

open access: yesAdvanced Science, EarlyView.
This study uncovers periodic contrast reversal in ultrasmall skyrmion lattice imaging through defocus‐modulated Fresnel magnetic microscopy, elucidating its origin in the sinusoidal contrast transfer function mechanism and providing fundamental insights into defocus‐mediated phase‐to‐intensity conversion processes in nanoscale magnetic imaging ...
Yongsen Zhang   +11 more
wiley   +1 more source

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