Categorical Smoothness of 4-Manifolds from Quantum Symmetries and the Information Loss Paradox. [PDF]
Król J, Asselmeyer-Maluga T.
europepmc +1 more source
Optimization of CRISPR/Cas9‐mediated CtPDS knockout in guar protoplasts
Abstract Guar (Cyamopsis tetragonoloba L. Taub.) is a climate‐resilient legume with industrial and agricultural applications. Recently, gene editing has emerged as a key genetic tool for crop improvement. Despite its recent increasing value as a commodity for various uses, there is no documented report of gene editing work in guar to date.
Protik Kumar Ghosh +5 more
wiley +1 more source
Genome-wide chromosome architecture prediction reveals biophysical principles underlying gene structure. [PDF]
Chiang M +6 more
europepmc +1 more source
Improving mandibular reconstruction by using topology optimization, patient specific design and additive manufacturing?-A biomechanical comparison against miniplates on human specimen. [PDF]
Lang JJ +11 more
europepmc +1 more source
ABSTRACT Antibody‐drug conjugates (ADCs) are innovative drugs composed of cytotoxic molecules (payload) linked to antibodies, that selectively target and kill cancer cells upon internalization. In vivo, ADCs exist as intact molecules, naked antibodies, or released, unconjugated (linker‐)payload.
Pauline L. M. Buitelaar +4 more
wiley +1 more source
Topoisomerase inhibitory activity of ethanolic extracts from botanicals <i>Coptis chinensis</i> and <i>Salvia officinalis</i>. [PDF]
Ingersoll W +4 more
europepmc +1 more source
ABSTRACT With the improvement of survival in multiple myeloma (MM), therapy‐related acute myeloid leukemia (t‐AML) has emerged as a clinically relevant second primary malignancy (SPM). We report a case of MM evolving into t‐AML after multi‐agent chemotherapy and review the literature on therapy‐related leukemias in MM.
Songdi Chen +10 more
wiley +1 more source
Structural insights into fungal and human topoisomerase II with implications for in silico antifungal drug design. [PDF]
Sappati S +3 more
europepmc +1 more source
Evaluating Multi‐Model and Multi‐Metric Approaches to Low‐Flow Simulation in Irish Catchments
Daily streamflow from 125 catchments was simulated using 47 conceptual models available in MARRMoT framework. The models were calibrated using two objective functions (log NSE and inverse KGE) focusing low flows. Model performances and choice of objective function were assessed against 18 catchment characteristics. ABSTRACT Climate change has increased
Sri Gowthami Vengana +2 more
wiley +1 more source

