Results 151 to 160 of about 17,588 (197)
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Isolation and structural confirmation of N -desmethyl topotecan, a metabolite of topotecan
Cancer Chemotherapy and Pharmacology, 1997A sensitive high-performance liquid chromatography (HPLC) method for the determination of topotecan and total levels of topotecan (lactone plus its ring-opened hydroxycarboxylate form) was developed by the authors and used in several pharmacokinetics studies. During the analysis of plasma and urine samples collected in those studies, an additional peak
Rosing, H. +6 more
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Clinical Pharmacokinetics of Topotecan
Clinical Pharmacokinetics, 1996Topotecan (Hycamtin), a semisynthetic water-soluble derivative of camptothecin, is a potent inhibitor of DNA topoisomerase I in vitro and has demonstrated encouraging antitumour activity in a wide variety of tumours, including ovarian cancer and small cell lung cancer.
Herben, V.M.M. +2 more
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Activity of topotecan in retinoblastoma
Ophthalmic Genetics, 2004To report our experience with topotecan in children with relapsed/refractory metastatic and intraocular retinoblastoma.Topotecan was administered intravenously as a 30-min infusion at a dose of 2 mg/m2/d for five consecutive days and repeated after three weeks.
Guillermo L, Chantada +5 more
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International Journal of Gynecological Cancer, 2007
Recurrent and advanced cervical cancers are associated with high mortality and a lack of effective treatment options, especially for women who are poor candidates for surgery or radiation therapy. The broad clinical effectiveness and manageable toxicity of topotecan in other human malignancies as well as promising recent study results suggest that it ...
S, Ackermann +3 more
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Recurrent and advanced cervical cancers are associated with high mortality and a lack of effective treatment options, especially for women who are poor candidates for surgery or radiation therapy. The broad clinical effectiveness and manageable toxicity of topotecan in other human malignancies as well as promising recent study results suggest that it ...
S, Ackermann +3 more
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Topotecan-induced Bronchiolitis
Southern Medical Journal, 2004Topotecan HCl is an antitumor drug exhibiting topoisomerase 1-inhibitory activity. Topotecan is used in the treatment of metastatic carcinoma of the ovary and as second-line treatment of small-cell lung cancer. Reported dose-limiting adverse reactions to topotecan are primarily hematologic in nature.
Colin C, Edgerton +2 more
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Topotecan (Hycamptin) and Topotecan‐Containing Regimens in the Treatment of Hematologic Malignancies
Annals of the New York Academy of Sciences, 2000Abstract: Single‐agent topotecan is an active drug in chemotherapy‐naive MDS and CMML and, to a lesser degree, in refractory/relapsed acute leukemias, low‐/intermediate‐grade lymphoma, and myeloma. Its combination with cytosine arabinoside induces complete remissions in high‐risk MDS/CMML.
M, Beran, H M, Kantarjian
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