Results 41 to 50 of about 25,780 (241)

Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model

Drug Delivery, 2018
Intravenous (IV) topotecan is approved for the treatment of various malignancies including lung cancer but its clinical use is greatly undermined by severe hematopoietic toxicity. We hypothesized that inhalation delivery of topotecan would increase local
Philip J. Kuehl, Marcie J. Grimes, Devon Dubose, Michael Burke, David A. Revelli, Andrew P. Gigliotti, Steven A. Belinsky, Mathewos Tessema   +7 more
doaj   +1 more source

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. [PDF]

PLoS ONE, 2016
Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc's) that must be resolved before gene transcription and DNA replication can proceed.
Angela M Mabb, Jeremy M Simon, Ian F King, Hyeong-Min Lee, Lin-Kun An, Benjamin D Philpot, Mark J Zylka   +6 more
doaj   +1 more source

Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors—New Usnic Acid Derivatives

International Journal of Molecular Sciences
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme and one of the causes of tumor resistance to topoisomerase 1 inhibitors such as topotecan.
T. E. Kornienko, A. Chepanova, A. Zakharenko, A. Filimonov, O. Luzina, N. Dyrkheeva, V. Nikolin, N. A. Popova, N. Salakhutdinov, O. Lavrik   +9 more
semanticscholar   +1 more source

Synthetic Lethal Screen Identifies NF-κB as a Target for Combination Therapy with Topotecan for patients with Neuroblastoma

BMC Cancer, 2012
Background Despite aggressive multimodal treatments the overall survival of patients with high-risk neuroblastoma remains poor. The aim of this study was to identify novel combination chemotherapy to improve survival rate in patients with high-risk ...
Tsang Patricia S, Cheuk Adam T, Chen Qing-Rong, Song Young K, Badgett Thomas C, Wei Jun S, Khan Javed   +6 more
doaj   +1 more source

Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery. [PDF]

PLoS ONE, 2016
Extraocular retinoblastoma is a major challenge worldwide, especially in developing countries. Current treatment involves the administration of systemic chemotherapy combined with radiation, but there is a clear need for improvement of chemotherapy ...
Paula Taich, Flavio Requejo, Marcelo Asprea, Mariana Sgroi, Pierre Gobin, David H Abramson, Guillermo Chantada, Paula Schaiquevich   +7 more
doaj   +1 more source

Setting up an Intra‐Arterial Chemotherapy Center in a Low‐Resource Country in Sub‐Saharan Africa [PDF]

Public Health Chall
Ghana established West Africa's first intra‐arterial chemotherapy service for retinoblastoma through a public–private partnership between Korle Bu Teaching Hospital and Euracare, delivering 32 treatment sessions for 10 children. Strategic partnerships, training, and phased implementation can make this vision‐ and life‐saving therapy achievable in low ...
Essuman V, Sarkodie B, Ofori‐Adjei D, Beyuo V, Nimako A, Bosompem A, Owusu‐Asare L, Essuman Y, Abaidoo B, Osei F, Jatoe D, Renner L, Tagoe N, Amissah‐Arthur K.   +13 more
europepmc   +2 more sources

The Role of Cryotherapy in Vitreous Concentrations of Topotecan Delivered by Episcleral Hydrogel Implant

Pharmaceutics, 2022
Transscleral diffusion delivery of chemotherapy is a promising way to reach the vitreal seeds of retinoblastoma, the most common intraocular malignancy in childhood.
Martina Kodetova, Radka Hobzova, Jakub Sirc, Jiri Uhlik, Katerina Dunovska, Karel Svojgr, Ana-Irina Cocarta, Andrea Felsoova, Ondrej Slanar, Martin Sima, Igor Kozak, Pavel Pochop   +11 more
doaj   +1 more source

A randomised phase 2b study comparing the efficacy and safety of belotecan vs. topotecan as monotherapy for sensitive-relapsed small-cell lung cancer

British Journal of Cancer, 2020
This study compared the efficacy/safety of the camptothecin analogues belotecan and topotecan for sensitive-relapsed small-cell lung cancer (SCLC). One-hundred-and-sixty-four patients were randomised (1:1) to receive five consecutive daily intravenous ...
Jin-Hyoung Kang, K. Lee, Dong-wan Kim, Sang-We Kim, H. Kim, J. Kim, Jin-Hyuk Choi, H. An, Jin-Soo Kim, J. Jang, Bongseog Kim, H. Kim   +11 more
semanticscholar   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Hyaluronic acid–targeted topotecan liposomes improve therapeutic efficacy against lung cancer in animals

Frontiers in Oncology
Lung cancer, as a serious threat to human health and life, necessitating urgent treatment and intervention. In this study, we prepared hyaluronic acid (HA)-targeted topotecan liposomes for site-specific delivery to tumor cells.
Gangqiang Xue, Lu Tang, Xinyan Pan, Sanni Li, Juan Zhao   +4 more
doaj   +1 more source