Results 51 to 60 of about 25,780 (241)

Is Intravitreal Topotecan Toxic to Retinal Function?

British Journal of Ophthalmology, 2020
Background Intravitreal injections of topotecan are used in the management of retinoblastoma with vitreous seeds. This study evaluated whether intravitreal topotecan was associated with retinal toxicity.
Jennifer B Nadelmann, J. Francis, S. Brodie, Engjel Muca, D. Abramson   +4 more
semanticscholar   +1 more source

Patient‐reported outcomes and medication errors during oral antitumour therapy in paediatrics: Results from the youngAMBORA care programme

British Journal of Clinical Pharmacology, EarlyView.
Aim Increasing use of oral antitumour therapeutics (OAT) in paediatrics is associated with numerous advantages, but also with error‐prone aspects. Based on the randomized AMBORA trial including adults treated with various OAT, we developed a tailored pharmacological/pharmaceutical care programme for children and their caregivers during OAT treatment ...
Phyllis Lensker, Lisa Cuba, Frank Dörje, Martin F. Fromm, Markus Metzler   +4 more
wiley   +1 more source

Intravitreal topotecan inhibits laser-induced choroidal neovascularization in a rat model

Journal of Ophthalmic & Vision Research, 2015
Purpose: A two-phase preclinical study was designed to determine the safe dose of intravitreal topotecan and its inhibitory effect on experimental choroidal neovascularization (CNV) in a rat model.
Mohammad Ali Gholipour, Mozhgan Rezaei Kanavi, Hamid Ahmadieh, Seyed Javid Aldavood, Ramin Nourinia, Seyed Bagher Hosseini, Narsis Daftarian, Ebrahim Mohammad Nashtaei, Adib Tousi, Sare Safi   +9 more
doaj   +1 more source

Investigation of Topotecan and Folic Acid Effect in Jar Choriocarcinoma Cell Culture

Batı Karadeniz Tıp Dergisi, 2021
Aim: The purpose of this study is to search the effects and treatment efficacies of topotecan and folicacid on the choriocarcinoma cultures generated in JAR cell culture.Material and Methods: Human choriocarcinoma-like JAR cell is augmented in the 10 ...
Rahşan Eyüp Doğan, Aykut Barut, Görker Sel, Müge Harma, Mehmet Harma, İshak Özel Tekin   +5 more
doaj   +1 more source

Multidimensional Engineering Enabling Rate‐Matched C−N Coupling for Efficient Organonitrogen Electrosynthesis

EcoEnergy, EarlyView.
This review introduces rate matching as a unifying design principle for efficient electrochemical C−N coupling and highlights multidimensional engineering of catalysts, interfaces, and reactors to synchronize the generation of carbon‐ and nitrogen‐containing intermediates, balance their surface coverages, maximize C−N bond formation, and enable ...
Kaixing Cai, Chunyang Pu, Jun Yang, Guangqin Li, Jiahui Xian   +4 more
wiley   +1 more source

Preclinical pharmacology and clinical uses of topotecan

, 1999
Topotecan, a soluble semisynthetic derivative of camptothecin, is a specific inhibitor of topoisomerase I and is endowed of potent antiproliferative effect in vitro and in vivo on tumoral cell lines as well as on endothelial cells. Moreover, topotecan is
DEL TACCA M, DANESI, ROMANO, DI PAOLO, ANTONELLO   +2 more
core   +3 more sources

EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors. [PDF]

PLoS ONE, 2012
BRCA1 dysfunction in hereditary breast cancer causes defective homology-directed DNA repair and sensitivity towards DNA damaging agents like the clinically used topoisomerase I inhibitors topotecan and irinotecan.
Serge A L Zander, Wendy Sol, Lee Greenberger, Yixian Zhang, Olaf van Tellingen, Jos Jonkers, Piet Borst, Sven Rottenberg   +7 more
doaj   +1 more source

Cytotoxic and Pro‐Apoptotic Effects of the Compound 2‐Carboxy‐2‐Heptano‐Indolin‐3‐One in HeLa Cell Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Indolinones are compounds with recognized antineoplastic properties and can act as inhibitors of multiple kinases. However, the antitumor effects of 2‐carboxy‐2‐heptano‐indolin‐3‐one (IDC) have not yet been investigated in cervical cancer models.
Agda Lorena Corrêa Rocha, Caroline Fernandes Westin, Erika Tyemi Goya Niekawa, Galdino Andrade, Luan Vitor Alves de Lima, Lucas Karpinski Risson, Matheus Felipe da Silva, Stefani Fabiola Alarcon, Mário Sérgio Mantovani   +8 more
wiley   +1 more source

Topotecan lacks third space sequestration [PDF]

, 2000
The objective of this study was to determine the influence of pleural and ascitic fluid on the pharmacokinetics of the antitumor camptothecin derivative topotecan.
Loos, W.J. (Walter), Jonge, M.J.A. (Maja) de, Verweij, J. (Jaap), Gelderblom, A.J. (Hans), Sparreboom, A. (Alex)   +4 more
core   +1 more source

Bevacizumab‐Associated Eczema Herpeticum in Metastatic Ovarian Carcinoma: A Case Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Eczema herpeticum (EH) is a rare but potentially life‐threatening cutaneous infection caused by herpes simplex virus (HSV), classically associated with atopic dermatitis. Its occurrence in oncology patients receiving anti‐angiogenic targeted therapy and cytotoxic chemotherapy is exceedingly uncommon.
Mandeep Dutta Joshi, Nishant Pandey, Sushan Ghimire, Avilasha Shah, Anurag Tiwari, Salina Subedi, Deepika Neupane   +6 more
wiley   +1 more source