Results 71 to 80 of about 25,780 (241)
High-dose topotecan (90 and 180 μG) for recurrent subretinal and vitreous seeding in retinoblastoma
American Journal of Ophthalmology Case ReportsPurpose: To report on the use of intravitreal high-dose topotecan (90 and 180 μG) for recurrent subretinal and vitreous retinoblastoma, the toxicity of these injections, and the use of a 180-μG injection of intravitreal topotecan in humans. Observations:
David H. Abramson, Jasmine H. Francis
doaj +1 more source
Pharmacologic topoisomerase-I inhibition causes DNA damage and mortality in activated CD4+ T cells
Genetics & Applications, 2018 Topoisomerase-I is required for DNA replication. It acts by preventing torsional stress caused by DNA winding during replication fork progression. Topoisomerase-I inhibitors are widely used in many cancer therapies, in light of their anti-proliferative ...
Mia Stanić +2 more
doaj +3 more sources
Topotecan for ovarian cancer [PDF]
Cochrane Database of Systematic Reviews, 2008 Chemotherapeutic agents such as topotecan can be used to treat ovarian cancer. The effects of using topotecan as a therapeutic agent have not been previously been systematically reviewed.To systematically evaluate the effectiveness and safety of topotecan for the treatment of ovarian cancer.We searched the Cochrane Central Register of Controlled Trials
Minawaer Abudou +3 more
openaire +2 more sources
A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
PLoS ONE, 2013 Gliomas, the most malignant form of brain tumors, contain a small subpopulation of glioma stem cells (GSCs) that are implicated in therapeutic resistance and tumor recurrence.
Feng-Lei Zhang +6 more
doaj +1 more source
Journal of Clinical Oncology, 2017 Purpose Our preclinical work identified depletion of ATR as a top candidate for topoisomerase 1 (TOP1) inhibitor synthetic lethality and showed that ATR inhibition sensitizes tumors to TOP1 inhibitors.
Anish Thomas +23 more
semanticscholar +1 more source
Oral Diseases, EarlyView.ABSTRACT Objective Oral cavity squamous cell carcinoma (OCSCC) is the predominant subtype of head and neck squamous cell carcinoma in Taiwan. Despite the guideline‐recommended adjuvant chemoradiotherapy (CRT) for advanced pathological risk factors, long‐term survival remains suboptimal.
Hsueh‐Ju Lu +7 more
wiley +1 more source
BMC CancerObjectives Synthetic data may proxy clinical data. At the absence of direct clinical data, this study aimed to compare Irinotecan and Ifosfamide (II) with Topotecan in synthetic, recurrent small cell lung cancer (SCLC) patients within a simulated ...
Hakan Şat Bozcuk, Mehmet Artaç
doaj +1 more source
Toxicology ReportsBackground: Colorectal cancer (CRC) is one of the most common cancers worldwide, yet it continues to have a low survival rate, largely due to the lack of effective treatments.
Yousra A. Hagyousif +14 more
doaj +1 more source
Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells. [PDF]
PLoS ONE, 2016 Current treatment of retinoblastoma involves using the maximum dose of chemotherapy that induces tumor control and is tolerated by patients. The impact of dose and schedule on the cytotoxicity of chemotherapy has not been studied.
Ursula Winter +9 more
doaj +1 more source