Results 61 to 70 of about 17,588 (197)

Pharmacologic topoisomerase-I inhibition causes DNA damage and mortality in activated CD4+ T cells

Genetics & Applications, 2018
Topoisomerase-I is required for DNA replication. It acts by preventing torsional stress caused by DNA winding during replication fork progression.  Topoisomerase-I inhibitors are widely used in many cancer therapies, in light of their anti-proliferative ...
Mia Stanić, Iart Luca Shytaj, Marina Lusic   +2 more
doaj   +3 more sources

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Topoisomerase I inhibitors, shikonin and topotecan, inhibit growth and induce apoptosis of glioma cells and glioma stem cells.

PLoS ONE, 2013
Gliomas, the most malignant form of brain tumors, contain a small subpopulation of glioma stem cells (GSCs) that are implicated in therapeutic resistance and tumor recurrence.
Feng-Lei Zhang, Ping Wang, Yun-Hui Liu, Li-Bo Liu, Xiao-Bai Liu, Zhen Li, Yi-Xue Xue   +6 more
doaj   +1 more source

Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells. [PDF]

PLoS ONE, 2016
Current treatment of retinoblastoma involves using the maximum dose of chemotherapy that induces tumor control and is tolerated by patients. The impact of dose and schedule on the cytotoxicity of chemotherapy has not been studied.
Ursula Winter, Hebe A Mena, Soledad Negrotto, Eloisa Arana, Guillem Pascual-Pasto, Viviana Laurent, Mariona Suñol, Guillermo L Chantada, Angel M Carcaboso, Paula Schaiquevich   +9 more
doaj   +1 more source

Lactone Stabilized by Crosslinked Cyclodextrin Metal-Organic Frameworks to Improve Local Bioavailability of Topotecan in Lung Cancer

Pharmaceutics, 2022
The protection of unstable anticancer molecules and their delivery to lesions are challenging issues in cancer treatment. Topotecan (TPT), a classic cytotoxic drug, is widely used for treating refractory lung cancer.
Ting Xiong, Tao Guo, Yaping He, Zeying Cao, Huipeng Xu, Wenting Wu, Li Wu, Weifeng Zhu, Jiwen Zhang   +8 more
doaj   +1 more source

Topotecan for ovarian cancer [PDF]

Cochrane Database of Systematic Reviews, 2008
Chemotherapeutic agents such as topotecan can be used to treat ovarian cancer. The effects of using topotecan as a therapeutic agent have not been previously been systematically reviewed.To systematically evaluate the effectiveness and safety of topotecan for the treatment of ovarian cancer.We searched the Cochrane Central Register of Controlled Trials
Minawaer Abudou, Dake Zhong, Taixiang Wu, XiaoKe Wu   +3 more
openaire   +2 more sources

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, Volume 13, Issue 49, 3 September 2026.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Optimization of liposomal topotecan for use in treating neuroblastoma [PDF]

, 2017
The purpose of this work was to develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Drug exposure time studies were used to determine that topotecan (Hycamtin) exhibited great cytotoxic ...
Gilabert-Oriol, R, Anantha, M, Bally, MB, Dos Santos, N, Deyell, RJ, Chernov, L   +5 more
core   +1 more source

A simulated trial with reinforcement learning for the efficacy of Irinotecan and Ifosfamide versus Topotecan in relapsed, extensive stage small cell lung cancer

BMC Cancer
Objectives Synthetic data may proxy clinical data. At the absence of direct clinical data, this study aimed to compare Irinotecan and Ifosfamide (II) with Topotecan in synthetic, recurrent small cell lung cancer (SCLC) patients within a simulated ...
Hakan Şat Bozcuk, Mehmet Artaç
doaj   +1 more source

Molecular signatures of xenograft colorectal cancer in mice treated with topotecan: A mass spectrometry-based study

Toxicology Reports
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide, yet it continues to have a low survival rate, largely due to the lack of effective treatments.
Yousra A. Hagyousif, Ruba A. Zenati, Nelson C. Soares, Hamza M. Al-Hroub, Farman Matloob Khan, Rizwan Qaisar, Rifat Hamoudi, Raafat El-Awady, Ahmad Y. Abuhelwa, Wafaa Ramadan, Waseem El-Huneidi, Eman Abu-Gharbieh, Karem H. Alzoubi, Yasser Bustanji, Mohammad H. Semreen   +14 more
doaj   +1 more source