Results 191 to 200 of about 25,780 (241)

Clinical Pharmacokinetics of Topotecan

Clinical Pharmacokinetics, 1996
Topotecan (Hycamtin), a semisynthetic water-soluble derivative of camptothecin, is a potent inhibitor of DNA topoisomerase I in vitro and has demonstrated encouraging antitumour activity in a wide variety of tumours, including ovarian cancer and small cell lung cancer.
Herben, V.M.M., ten Bokkel Huinink, W.W., Beijnen, J.H.   +2 more
openaire   +3 more sources

Isolation and structural confirmation of N -desmethyl topotecan, a metabolite of topotecan

Cancer Chemotherapy and Pharmacology, 1997
A sensitive high-performance liquid chromatography (HPLC) method for the determination of topotecan and total levels of topotecan (lactone plus its ring-opened hydroxycarboxylate form) was developed by the authors and used in several pharmacokinetics studies. During the analysis of plasma and urine samples collected in those studies, an additional peak
Rosing, H., Herben, V.M.M., van Gortel-van Zomeren, D.M., Hop, E., Kettenes-van den Bosch, J.J., ten Bokkel Huinink, W.W., Beijnen, J.H.   +6 more
openaire   +3 more sources

Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan.

Journal of Medicinal Chemistry, 2018
Chemical probes of microRNA (miRNA) function are potential tools for understanding miRNA biology that also provide new approaches for discovering therapeutics for miRNA-associated diseases. MicroRNA-21 (miR-21) is an oncogenic miRNA that is overexpressed
Yuta Naro, Nicholas Ankenbruck, M. Thomas, Yaniv Tivon, C. Connelly, Laura Gardner, A. Deiters   +6 more
semanticscholar   +1 more source

Formulation and optimization of topotecan nanoparticles: In vitro characterization, cytotoxicity, cellular uptake and pharmacokinetic outcomes.

Journal of Photochemistry and Photobiology. B: Biology, 2018
The study focuses on widening up the therapeutic perspective of anti-cancer therapy by entrapping a hydrophilic anticancer drug, topotecan hydrochloride (TOPO) in biodegradable poly (lactide-co-glycolide) (PLGA) matrix to form topotecan nanoparticles ...
Santwana Padhi, R. Kapoor, Devina Verma, A. Panda, Z. Iqbal   +4 more
semanticscholar   +1 more source

Topotecan in cervical cancer

International Journal of Gynecological Cancer, 2007
Recurrent and advanced cervical cancers are associated with high mortality and a lack of effective treatment options, especially for women who are poor candidates for surgery or radiation therapy. The broad clinical effectiveness and manageable toxicity of topotecan in other human malignancies as well as promising recent study results suggest that it ...
S, Ackermann, M W, Beckmann, F, Thiel, T, Bogenrieder   +3 more
openaire   +2 more sources

Topotecan-induced Bronchiolitis

Southern Medical Journal, 2004
Topotecan HCl is an antitumor drug exhibiting topoisomerase 1-inhibitory activity. Topotecan is used in the treatment of metastatic carcinoma of the ovary and as second-line treatment of small-cell lung cancer. Reported dose-limiting adverse reactions to topotecan are primarily hematologic in nature.
Colin C, Edgerton, Matthew, Gilman, Bernard J, Roth   +2 more
openaire   +2 more sources

Synergic effect of 2D nitrogen doped reduced graphene nano-sheet and ionic liquid as a new approach for fabrication of anticancer drug sensor in analysis of doxorubicin and topotecan

Journal of Molecular Liquids, 2018
The determination of doxorubicin and topotecan as two important breast anticancer drugs with high side effects is significant in pharmaceutical samples.
A. Mohammadian, M. Ebrahimi, H. Karimi-Maleh   +2 more
semanticscholar   +1 more source

Activity of topotecan in retinoblastoma

Ophthalmic Genetics, 2004
To report our experience with topotecan in children with relapsed/refractory metastatic and intraocular retinoblastoma.Topotecan was administered intravenously as a 30-min infusion at a dose of 2 mg/m2/d for five consecutive days and repeated after three weeks.
Guillermo L, Chantada, Adriana C, Fandiño, Sandra J, Casak, Gabriel, Mato, Julio, Manzitti, Enrique, Schvartzman   +5 more
openaire   +2 more sources

Topotecan (Hycamptin) and Topotecan‐Containing Regimens in the Treatment of Hematologic Malignancies

Annals of the New York Academy of Sciences, 2000
Abstract: Single‐agent topotecan is an active drug in chemotherapy‐naive MDS and CMML and, to a lesser degree, in refractory/relapsed acute leukemias, low‐/intermediate‐grade lymphoma, and myeloma. Its combination with cytosine arabinoside induces complete remissions in high‐risk MDS/CMML.
M, Beran, H M, Kantarjian
openaire   +2 more sources

Topotecan

Journal of Pediatric Oncology Nursing, 1992
D L, Betcher, N, Burnham
openaire   +2 more sources