Results 31 to 40 of about 13,871 (164)

Effects of Pazopanib Monotherapy vs. Pazopanib and Topotecan Combination on Anaplastic Thyroid Cancer Cells

Frontiers in Oncology, 2019
The purpose of this study was to examine pazopanib/topotecan combination activity vs. pazopanib monotherapy on anaplastic thyroid cancer (ATC) cells.
Teresa Di Desidero, Paola Orlandi, Daniela Gentile, Guido Bocci   +3 more
doaj   +1 more source

Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model

Drug Delivery, 2018
Intravenous (IV) topotecan is approved for the treatment of various malignancies including lung cancer but its clinical use is greatly undermined by severe hematopoietic toxicity. We hypothesized that inhalation delivery of topotecan would increase local
Philip J. Kuehl, Marcie J. Grimes, Devon Dubose, Michael Burke, David A. Revelli, Andrew P. Gigliotti, Steven A. Belinsky, Mathewos Tessema   +7 more
doaj   +1 more source

HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model [PDF]

PeerJ, 2019
Purpose The therapeutic approach for retinal ganglion cell (RGC) degeneration has not been fully established. Recently, it has been reported that hypoxia-inducible factor (HIF) may be involved with retinal neurodegeneration.
Hiromitsu Kunimi, Yukihiro Miwa, Yusaku Katada, Kazuo Tsubota, Toshihide Kurihara   +4 more
doaj   +2 more sources

Synthetic Lethal Screen Identifies NF-κB as a Target for Combination Therapy with Topotecan for patients with Neuroblastoma

BMC Cancer, 2012
Background Despite aggressive multimodal treatments the overall survival of patients with high-risk neuroblastoma remains poor. The aim of this study was to identify novel combination chemotherapy to improve survival rate in patients with high-risk ...
Tsang Patricia S, Cheuk Adam T, Chen Qing-Rong, Song Young K, Badgett Thomas C, Wei Jun S, Khan Javed   +6 more
doaj   +1 more source

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. [PDF]

PLoS ONE, 2016
Topoisomerase 1 (TOP1) inhibitors, including camptothecin and topotecan, covalently trap TOP1 on DNA, creating cleavage complexes (cc's) that must be resolved before gene transcription and DNA replication can proceed.
Angela M Mabb, Jeremy M Simon, Ian F King, Hyeong-Min Lee, Lin-Kun An, Benjamin D Philpot, Mark J Zylka   +6 more
doaj   +1 more source

Is Intravenous and Oral Topotecan in Small-Cell Lung Cancer Truly Equal? A Case Report

Case Reports in Oncology
Introduction: Treatment with topotecan is standard-of-care therapy for relapsed small-cell lung cancer (SCLC). Both oral and intravenous administrations of topotecan have been extensively researched and are found to be equally effective with less adverse
Davien Deraedt, Saartje Verfaillie, Jokke Wynants, Kristof Cuppens   +3 more
doaj   +1 more source

Triggering of Suicidal Erythrocyte Death by Topotecan

Cellular Physiology and Biochemistry, 2015
Background/Aims: The topoisomerase I inhibitor topotecan is used as treatment of various malignancies. The substance is effective by triggering tumor cell apoptosis. In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis, a suicidal
Rosi Bissinger, Ghada Bouguerra, Katja Stockinger, Salem Abbès, Florian Lang   +4 more
doaj   +1 more source

Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery. [PDF]

PLoS ONE, 2016
Extraocular retinoblastoma is a major challenge worldwide, especially in developing countries. Current treatment involves the administration of systemic chemotherapy combined with radiation, but there is a clear need for improvement of chemotherapy ...
Paula Taich, Flavio Requejo, Marcelo Asprea, Mariana Sgroi, Pierre Gobin, David H Abramson, Guillermo Chantada, Paula Schaiquevich   +7 more
doaj   +1 more source

The Role of Cryotherapy in Vitreous Concentrations of Topotecan Delivered by Episcleral Hydrogel Implant

Pharmaceutics, 2022
Transscleral diffusion delivery of chemotherapy is a promising way to reach the vitreal seeds of retinoblastoma, the most common intraocular malignancy in childhood.
Martina Kodetova, Radka Hobzova, Jakub Sirc, Jiri Uhlik, Katerina Dunovska, Karel Svojgr, Ana-Irina Cocarta, Andrea Felsoova, Ondrej Slanar, Martin Sima, Igor Kozak, Pavel Pochop   +11 more
doaj   +1 more source

Therapeutic uses of topotecan for thoracic malignancies

Oncology Reviews, 2011
Topotecan, a topoisomerase 1 inhibitor (topo1-i), is a semi-synthetic derivative of camptothecan with wellestablished cytotoxic properties. It is licensed for the treatment of relapsed, sensitive small cell lung cancer (SCLC) and for second line ...
Saoirse O. Dolly, Craig P. Carden, James S. Myerson, Martina Puglisi, Mary E. O’Brien   +4 more
doaj   +1 more source