Results 61 to 70 of about 13,861 (164)

Molecular signatures of xenograft colorectal cancer in mice treated with topotecan: A mass spectrometry-based study

Toxicology Reports
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide, yet it continues to have a low survival rate, largely due to the lack of effective treatments.
Yousra A. Hagyousif, Ruba A. Zenati, Nelson C. Soares, Hamza M. Al-Hroub, Farman Matloob Khan, Rizwan Qaisar, Rifat Hamoudi, Raafat El-Awady, Ahmad Y. Abuhelwa, Wafaa Ramadan, Waseem El-Huneidi, Eman Abu-Gharbieh, Karem H. Alzoubi, Yasser Bustanji, Mohammad H. Semreen   +14 more
doaj   +1 more source

Treatment patterns and clinical outcomes in real‐world patients with small‐cell lung cancer in South Korea: A single‐center experience

International Journal of Cancer, Volume 159, Issue 3, Page 719-728, 1 August 2026.
What's New? The emerging role of immunotherapy in small‐cell lung cancer treatment has not been fully elucidated, particularly outside of clinical trials. This single‐center retrospective cohort study examined real‐world treatment patterns and overall survival in South Korea during the 2018–2023 period.
Sehhoon Park, Danbee Kang, Jin Lee, Hyun Ae Jung, Jong‐Mu Sun, Se‐Hoon Lee, Jin Seok Ahn, Hojoon Lee, Hyuna Lim, Xerxes Pundole, Juhee Cho, Myung‐Ju Ahn   +11 more
wiley   +1 more source

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, Volume 159, Issue 2, Page 460-466, 15 July 2026.
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Sustained Complete Response after Maintenance Therapy with Topotecan and Erlotinib for Recurrent Cervical Cancer with Distant Metastases

Case Reports in Oncology, 2014
Introduction: Recurrent cervical cancer is associated with a poor prognosis. Most treatment responses are partial and of short duration. The development of new therapies is vital to improve treatment for recurrent disease.
Donato Callegaro-Filho, John J. Kavanagh, Alpa M. Nick, Pedro T. Ramirez, Kathleen M. Schmeler   +4 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Duocarmycin‐Bearing Antibody‐Mimetic Drug Conjugate Combined With an ATR Inhibitor Results in Complete Tumor Regression in a KPL‐4 Xenograft Model

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Antibody–drug conjugates (ADCs) have demonstrated superior clinical outcomes in patients with HER2‐positive advanced breast cancer compared with previous treatment modalities. However, resistance and treatment‐limiting toxicities frequently emerge during repeated administration, underscoring an unmet need for strategies to overcome ADC failure.
Toshiya Tanaka, Akira Sugiyama, Juri Sakata, Toshifumi Tatsumi, Hiroto Katoh, Keisuke Maeda, Yuya Inagaki, Takefumi Yamashita, Takeshi Kawamura, Mayu Kuratani, Taiki Nakano, Masazumi Ishii, Mai Miura, Wakana Kamiya, Yuko Shiratori, Hisato Kitanoya, Michael Chansler, Naoki Harada, Masayuki Tsuchiya, Tsuyoshi Osawa, Shumpei Ishikawa, Tatsuhiko Kodama, Kenzo Yamatsugu, Hidetoshi Tokuyama, Motomu Kanai   +24 more
wiley   +1 more source

Pharmacokinetic Comparison of Three Different Administration Routes for Topotecan Hydrochloride in Rats

Pharmaceuticals, 2020
Topotecan is actively used in clinic, with its primary use being in treatment of various types of cancer. The approved administration routes are oral and intravenous.
Seung-Hyun Jeong, Ji-Hun Jang, Yong-Bok Lee   +2 more
doaj   +1 more source

Metronomic Chemotherapy in Ovarian Cancer: Current Scenario and AI‐Integrated Future Strategies

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Ovarian cancer (OC) is a globally prevalent malignancy associated with a high mortality rate and marked biological heterogeneity, with most cases arising from epithelial cells and presenting as serous, endometrioid, or clear cell subtypes.
Ravi Chauhan, Suraja Kumar Das, Lakshay Malhotra, Rajeev Goyal, Sameer Mirza, Khushi Nehra, Maysaloun Merhi, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Shweta Tripathi, Ajaz A. Bhat, Mayank Singh   +11 more
wiley   +1 more source

Potential Mechanisms of Trimetazidine and Coenzyme Q10 Against Antipsychotic‐Induced Myocarditis: A Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
In this study, we explored the mechanisms for the therapeutic effects of TMZ and CoQ10 on myocarditis using network pharmacology, molecular docking, and molecular dynamics simulations. Our findings identified core targets of TMZ and CoQ10 treatment of myocarditis; the five core targets included EGFR, MMP9, PPARG, AKT1, and CASP3.
Ximing Chen, Dongyin Zhuo, Jiatong Zou, Haitao Song, Kaifang Yao, Hongjun Tian, Chuanjun Zhuo   +6 more
wiley   +1 more source

A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Preclinical models for sarcoma that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. 29 early‐passage patient‐derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes were established and extensively characterized.
Stefanie Gijsels, Suzanne Fischer, David Creytens, Sándor Dedeyne, Felix De Vuyst, Cláudio Pinheiro, Fleur Cordier, Sarah‐Lee Bekaert, Nadine Van Roy, Kaat Durinck, Jarne Pauwels, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Pekka Rappu, Jyrki Heino, An Hendrix, Gabrielle H. van Ramshorst, Gwen Sys, Olivier De Wever   +19 more
wiley   +1 more source