Results 41 to 50 of about 11,023,269 (282)

Targeted NGS Platforms for Genetic Screening and Gene Discovery in Primary Immunodeficiencies

Frontiers in Immunology, 2019
Background: Primary Immunodeficiencies (PIDs) are a heterogeneous group of genetic immune disorders. While some PIDs can manifest with more than one phenotype, signs, and symptoms of various PIDs overlap considerably.
Cristina Cifaldi, Immacolata Brigida, Federica Barzaghi, Federica Barzaghi, Federica Barzaghi, Matteo Zoccolillo, Matteo Zoccolillo, Valentina Ferradini, Davide Petricone, Maria Pia Cicalese, Maria Pia Cicalese, Maria Pia Cicalese, Dejan Lazarevic, Davide Cittaro, Maryam Omrani, Enrico Attardi, Francesca Conti, Alessia Scarselli, Maria Chiriaco, Silvia Di Cesare, Francesco Licciardi, Montin Davide, Francesca Ferrua, Francesca Ferrua, Francesca Ferrua, Clementina Canessa, Clementina Canessa, Claudio Pignata, Silvia Giliani, Simona Ferrari, Georgia Fousteri, Graziano Barera, Pietro Merli, Paolo Palma, Simone Cesaro, Marco Gattorno, Antonio Trizzino, Viviana Moschese, Viviana Moschese, Loredana Chini, Loredana Chini, Anna Villa, Anna Villa, Chiara Azzari, Chiara Azzari, Andrea Finocchi, Andrea Finocchi, Franco Locatelli, Paolo Rossi, Paolo Rossi, Federica Sangiuolo, Alessandro Aiuti, Alessandro Aiuti, Alessandro Aiuti, Caterina Cancrini, Caterina Cancrini, Gigliola Di Matteo, Gigliola Di Matteo   +57 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Torrent erosion in Lake District mountain catchments. [PDF]

, 2001
This thesis investigates torrent erosion in Lake District mountain catchments,Northern England. A nested research approach was used. Detailed investigations were undertaken at two case study sites (Iron Crag, Raise Beck) together with a survey of ...
Johnson, R.M., Johnson, Richard Michael, Johnson, R.M   +2 more
core  

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Proces de mosen Frances Roch Torrent y altres en certs noms : Cort Civil. [PDF]

Explicit : "E per que al present trellat... tret de son original registre de la Cort Civil de Valencia... Joan Andreu... sig(signo)num"Incipit : "Anno... millessimo sexcentessimo decimo tercio die...
Valencia. Ciutat. Justicia Civil, Bleda, Antoni, Roch Torrent, Francesc   +2 more
core   +3 more sources

Impact of DNA Sequencing and Analysis Methods on 16S rRNA Gene Bacterial Community Analysis of Dairy Products

mSphere, 2018
DNA sequencing and analysis methods were compared for 16S rRNA V4 PCR amplicon and genomic DNA (gDNA) mock communities encompassing nine bacterial species commonly found in milk and dairy products.
Zhengyao Xue, Mary E. Kable, Maria L. Marco   +2 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Validation and interpretation of IGH and TCR clonality testing by Ion Torrent S5 NGS for diagnosis and disease monitoring in B and T cell cancers

Practical Laboratory Medicine, 2020
Cancers of B and T lymphocytes are the most common hematologic malignancies in the US. Molecular assays for assessing clonal rearrangements of the immunoglobulin receptor (IGH) and T-cell receptor (TCR), commonly referred to as B- and T-cell clonality ...
Lindsay Lay, Brooke Stroup, Jacqueline E. Payton   +2 more
doaj   +1 more source

Towards the validation of high-throughput sequencing (HTS) for routine plant virus diagnostics: measurement of variation linked to HTS detection of citrus viruses and viroids

Virology Journal, 2021
Background High-throughput sequencing (HTS) has been applied successfully for virus and viroid discovery in many agricultural crops leading to the current drive to apply this technology in routine pathogen detection.
Rachelle Bester, Glynnis Cook, Johannes H. J. Breytenbach, Chanel Steyn, Rochelle De Bruyn, Hans J. Maree   +5 more
doaj   +1 more source