Results 31 to 40 of about 480,913 (287)
OncoTarget, 2018 Anticancer drugs may have proarrhythmic effects including drug-induced QT interval prolongation, which is of particular importance because it can lead to a fatal polymorphic ventricular tachycardia termed torsade de pointes (TdP).
Jialin Duan +8 more
semanticscholar +1 more source
Adverse reactions of amiodarone [PDF]
, 2019 Adverse drug reaction is defined by the World Health Organization as any response to a drug that is noxious and unintended and occurs at a dose normally used in man.
Calvosa, Leonardo +5 more
core +1 more source
Journal of Pharmacological Sciences, 2016 We evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). Oseltamivir in doses of 3–30 mg/kg, i.v.
Yuji Nakamura +9 more
doaj +1 more source
Clinical Cardiology, 1993 AbstractThe polymorphic ventricular tachycardia torsade de pointes can occur in the congenital long QT syndromes or as a consequence of therapy with QT‐prolonging drugs. The latter can include not only antiarrhythmic drugs such as quinidine, but also a number of drugs which are not usually considered to have major cardiovascular effects: these include ...
openaire +2 more sources
The Contribution of National Spontaneous Reporting Systems to Detect Signals of Torsadogenicity: Issues Emerging from the ARITMO Project [PDF]
, 2015 Introduction: Spontaneous reporting systems (SRSs) are pivotal for signal detection, especially for rare events with a high drug-attributable component, such as torsade de pointes (TdP).
Antoniazzi, S. (Stefania) +12 more
core +7 more sources
Pharmacology Research & Perspectives, 2017 Several noncardiac drugs have been linked to cardiac safety concerns, highlighting the importance of post‐marketing surveillance and continued evaluation of the benefit‐risk of long‐established drugs.
A. Schlit +9 more
semanticscholar +1 more source
Long QT Syndrome and Perioperative Torsades de Pointes: What the Anesthesiologist Should Know.
Journal of Cardiothoracic and Vascular Anesthesia, 2020 Perioperative Torsade de Pointes (TdP) is a potentially fatal arrhythmia. The association between the prolongation of corrected QT (QTc) interval and TdP has been well described, but prolonged QTc interval is likely not to be a sole determinant.
N. Niimi +2 more
semanticscholar +1 more source
Frontiers in Physiology, 2018 Background: Acquired QT interval prolongation has been linked with malignant ventricular arrhythmias, such as torsade de pointes, in turn predisposing to sudden cardiac death. Increased dispersion of repolarization has been identified as a pro-arrhythmic
Gary Tse +13 more
doaj +1 more source
Hypocalcemic torsades de pointes
Journal of Electrocardiology, 1989 Torsades de pointes is a unique form of ventricular tachycardia that occurs in the presence of prolonged QT interval. Many predisposing factors have been identified. A classical form of torsades de pointes occurring in the presence of hypocalcemia and prolonged QT interval in an elderly woman is reported.
T, Akiyama +4 more
openaire +2 more sources
Spatial patterns of excitation at tissue and whole organ level due to early afterdepolarizations [PDF]
, 2017 Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we present
Alexander V. Panfilov +4 more
core +3 more sources