Results 91 to 100 of about 9,024 (223)

From Molecules to Machines: An Integrative Framework Linking Molecular Pathogenesis, Multi‐Factorial Risk, Risk Stratification, Clinical Management, and Artificial Intelligence in QT Prolongation and Sudden Cardiac Death

Clinical Cardiology, Volume 49, Issue 6, June 2026.
An integrative conceptual framework linking the five principal domains addressed in this review. Beginning at the molecular level, loss‐of‐function mutations in KCNQ1 and KCNH2 reduce outward repolarizing currents (IKs and IKr), while gain‐of‐function SCN5A mutations augment late inward sodium current (INa), establishing the genetic substrate for ...
Mojtaba Farjam, Mohammad Hosein Yazdanpanah, Narges Fereydouni   +2 more
wiley   +1 more source

Methadone-induced Torsades de Pointes Masquerading as Seizures

Clinical Practice and Cases in Emergency Medicine, 2017
The authors herein present the case of a 53-year-old female who was being treated as an outpatient for seizure disorder but was also receiving high-dose methadone therapy.
David C. Traficante, Gordon Feibish, John Kashani   +2 more
doaj   +1 more source

Ephedrine‐Triggered Torsades de Pointes in Two Patients Following Desflurane‐Induced QT Prolongation

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Desflurane‐induced QT prolongation followed by ephedrine‐triggered premature ventricular contractions led to torsades de pointes/ventricular fibrillation in two patients. These cases demonstrate sequential electrocardiographic progression and highlight the importance of careful vasopressor selection during general anesthesia.
Shinichi Harada, Yoshihiko Kagawa, Ryuji Okamoto, Yosuke Sakakura, Kaoru Dohi   +4 more
wiley   +1 more source

Torsades de pointes and acute de novo heart failure in a young woman

, 2010
Hypothyroidism is a rare metabolic cause of dilated cardiomyopathy that responds to substitution therapy. We report on a young woman who presented with torsades de pointes, severe heart failure and multiple organ failure due to longstanding untreated ...
Maudens, Gunther, De Pauw, Michel, Gevaert, Sofie, Benoit, Dominique   +3 more
core   +1 more source

Effects of pH on Nifekalant-Induced Electrophysiological Change Assessed in the Langendorff Heart Model of Guinea Pigs

Journal of Pharmacological Sciences, 2014
Since information regarding the effects of pH on the extent of nifekalant-induced repolarization delay and torsades de pointes remains limited, we assessed it with a Langendorff heart model of guinea pigs.
Katsuyuki Kazusa, Yuji Nakamura, Yudai Watanabe, Kentaro Ando, Atsushi Sugiyama   +4 more
doaj   +1 more source

Investigation of the Effects of Methylphenidate on Hemodynamic Parameters in Children With ADHD

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT This prospective observational study investigated the acute effects of a single 10 mg dose of methylphenidate (MPH) on hemodynamic and electrocardiographic parameters in 60 children aged 6–16 years newly diagnosed with Attention Deficit Hyperactivity Disorder (ADHD).
Caglar Charles Daniel Jaicks, Selman Vefa Yıldırım   +1 more
wiley   +1 more source

Ketoconazole induced torsades de pointes without concomitant use of QT interval-prolonging drug

, 2005
Ketoconazole Induced Torsades de Pointes Ketoconazole is not known to be proarrhythmic without concomitant use of QT interval-prolonging drugs. We report a woman with coronary artery disease who developed a markedly prolonged QT interval and torsades de ...
Mok, NS, Lam, CW, Lo, YK, Tsui, PT
core   +1 more source

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, Volume 121, Issue 6, Page 1616-1621, June 2026.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

Effects of Nacubactam and Its Metabolites on QTc Interval: A Pooled Analysis of Two Randomized Phase 1 Studies

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Nacubactam is a β‐lactamase inhibitor. Early‐phase studies with 1000/2000/4000/8000 mg nacubactam monotherapy were not powered to assess proarrhythmic risk. Therefore, this analysis pooled electrocardiogram data from two placebo‐controlled studies to quantify potential effects of nacubactam on cardiac repolarization.
Jun Morita, Sue McKendrick, Yuji Kumagai
wiley   +1 more source

Thorough QT/QTc Clinical Study to Evaluate the Effect of Remdesivir on Cardiac Repolarization in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT QT interval prolongation associated with drug administration is an important consideration in drug development. Patients with COVID‐19 are at increased risk for cardiac complications, and QT interval prolongation correlates with higher mortality.
Chi‐Chi Peng, Ran Duan, Mazin Abdelghany, Santosh Davies, Deqing Xiao, Anna Kwan, Ana Ruiz‐Garcia   +6 more
wiley   +1 more source