Results 81 to 90 of about 9,024 (223)

Torsades de Pointes associated with QT prolongation after catheter ablation of paroxysmal atrial fibrillation

Indian Pacing and Electrophysiology Journal, 2017
A 79-year-old woman who underwent catheter ablation for paroxysmal atrial fibrillation presented with Torsades de Pointes (TdP). Aggravation of prolonged QT interval which is most likely due to neural modulation by catheter ablation, played major role in
Yae Min Park, Mi Suk Cha, Woong Chol Kang, Mi-Seung Shin, Young-Hoon Kim, In Suck Choi, Eak Kyun Shin   +6 more
doaj   +1 more source

Extracellular ionic concentration modulates arrhythmias in a simulated population of human ventricular myocytes with long QT syndrome type 3

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustrating the in silico study pipeline. A total of 50,000 virtual myocytes were generated, which were then filtered to 7093 myocytes that fit experimentally constrained biomarkers for physiological electrical and calcium behaviour under wild‐type conditions.
Katherine Flannery, Jacob A. Miller, Steven Poelzing, Seth H. Weinberg   +3 more
wiley   +1 more source

Donepezil-induced torsades de pointes without QT prolongation

, 2013
We report a case of torsades de pointes (TdP) induced by donepezil without QT prolongation. An 86-year-old woman was admitted to our hospital because of a syncopal attack. She had been treated for Alzheimer's disease with donepezil.
Akashi, Shintaro, Nakashima, Tadaaki, Shimizu, Akihiko, Ogawa, Hiroshi, Hadano, Yasuyuki, Miyazaki, Yosuke, 清水, 昭彦, Kimura, Masayasu, Mochizuki, Mamoru, Wakeyama, Takatoshi, Iwami, Takahiro   +10 more
core   +1 more source

Torsades de pointes with a severely prolonged QT interval induced by an initial low dose sotalol intake

, 2007
Many drugs, including sotalol, have been implicated in prolonging QT interval and triggering torsades de pointes, a potentially fatal ventricular arrhythmia, especially during chronic therapy or in case of acute high dose toxicity.
Yilmaz M.B., Karadas F., Yilmaz A., Turgut O., Kendirlioglu O., Yalta K.   +5 more
core   +2 more sources

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Torsade de Pointes Induced by Hypokalemia from Imipenem and Piperacillin

Case Reports in Cardiology, 2017
Imipenem-cilastatin and piperacillin-tazobactam are two antibiotics with broad antimicrobial coverage. Besides the many well established adverse effects of these drugs, there have been few case reports of hypokalemia.
Varun Kumar, Sandeep Khosla, Monica Stancu   +2 more
doaj   +1 more source

Variable electrophysiology before and after block of the two delayed rectifier potassium channels in groups of isolated rabbit ventricular cells

British Journal of Pharmacology, Volume 183, Issue 13, Page 3685-3705, July 2026.
Abstract Background and Purpose Between‐cell differences in ventricular cardiomyocyte action potential duration (APD) and responses to ion channel block may contribute to pro‐arrhythmic dispersion of myocardial repolarisation. This study quantifies between‐cell physiological and pharmacological variability in the rabbit left ventricle (LV) and uses ...
Rebecca J. Gilchrist, Muhamad Hifzhudin Noor Aziz, Francis L. Burton, Radostin D. Simitev, Rachel C. Myles, Godfrey L. Smith   +5 more
wiley   +1 more source

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

QTc Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults

Journal of the American Geriatrics Society, EarlyView.
Francesco Fantin, Sara Fiorini, Anna Giani, Luana Giacobbe, Elena Zoico, Gianluca Trifirò, Rocco Micciolo, Mauro Zamboni   +7 more
wiley   +1 more source

Long QT Syndrome Type 5 With Coexisting KCNE1 and RYR2 Variants: A Diagnostic Ambiguity

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Long QT syndrome (LQTS) predisposes to syncope and sudden cardiac death. Type 5 LQTS, linked to KCNE1 variants, is rare. A teenage female presented with recurrent syncope. ECG showed QTc 485 ms. Genetic testing identified KCNE1 and RYR2 variants. Beta‐blockers and ICD prevented events.
Mohammad Hossein Nikoo, Hossein Fatemian, Amir Hossein Hassani, Mehrdad Rabiee Rad, Sara Mostafavi   +4 more
wiley   +1 more source