Results 71 to 80 of about 14,335 (221)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh +5 more
wiley +1 more source
ECG-Based Measurements of Drug-induced Repolarization Changes [PDF]
, 2015 The purpose of this thesis is to investigate the abnormal repolarization both in the cellular and the surface ECG along with their relationship. It has been identified that the certain morphological changes of the monophasic action potential are ...
Bhuiyan, Tanveer Ahmed
core +2 more sources
Response to equine cardiac adverse events during sports
Equine Veterinary Education, EarlyView.Summary Cardiac adverse events and sudden death are a feared scenario for equine veterinarians, with serious consequences for animal health, riders' safety and the social licence to operate equestrian sports. The response to equine cardiac adverse events (CAEs) during sports is poorly defined.
C. Navas de Solis +9 more
wiley +1 more source
Archives des maladies du coeur et des vaisseaux, 1994 Torsades de pointes are defined and characterised by specific, polymorphic but organised ventricular activation on the surface electrocardiogram. They constitute episodes of rapid tachycardia which are usually short lasting and terminate spontaneously. However, they may recur and persist, leading to syncope or sudden death.
L, Guize +4 more
openaire +4 more sources
A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). [PDF]
, 1998 MinK and MinK-related peptide I (MiRPI) are integral membrane peptides with a single transmembrane span. These peptides are active only when co-assembled with pore-forming K+ channel subunits and yet their role in normal ion channel behaviour is ...
Abbott, GW, Goldstein, SA
core
, 2009 Beetaadrenoblokaatorid on heterogeenne rühm ravimeid, mille esindajad võivad oma toimemehhanismilt olla mitteselektiivsed β1- ja β2-adrenoretseptorite antagonistid, selektiivsed β1-adrenoretseptorite antagonistid, beetaadrenoretseptorite osalised ...
Pokk, Paavo
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand +2 more
wiley +1 more source
Az antiaritmiás gyógyszerek proaritmiás hatását befolyásoló tényezők vizsgálata = Examination of the factors that influence the proarrhythmic effects of the antiarrhythmic drugs [PDF]
, 2008 Vizsgálataink során megállapítottuk, hogy az altatószerek módosítják a gyógyszerek proaritmiás hatását nyulakban. Mivel a vagotomia védő hatású volt, a vegetatív idegrendszer valószínűleg befolyásolja a gyógyszerek proaritmiás hatásait nyúlban, de ennek ...
Farkas, András
core
Palbociclib has no clinically relevant effect on the QTc interval in patients with advanced breast cancer. [PDF]
, 2018 The aim of this study was to assess the potential effects of palbociclib in combination with letrozole on QTc. PALOMA-2, a phase 3, randomized, double-blind, placebo-controlled trial, compared palbociclib plus letrozole with placebo plus letrozole in ...
Durairaj, Chandrasekar +12 more
core +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend We investigated the age‐ and sex‐related differences in the apicobasal repolarization gradient (ABRG) and evaluated their possible role inventricular arrhythmia vulnerability. Electrocardiographic imaging (ECGI) was performed in healthy subjects during sinus rhythm, and the average recovery time (RT) and activation–recovery ...
Vladimír Sobota +9 more
wiley +1 more source