Results 51 to 60 of about 7,771 (181)
Российский кардиологический журнал, 2002 The first experience of implanted cardioverter/ defibrillator in a patient with life-threatening torsades de pointes.
E. V. Kolpakov +3 more
doaj
hERG1 channels and potential therapeutics for long QT syndrome
The Journal of Physiology, EarlyView.Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider +3 more
wiley +1 more source
Indian Heart Journal, 2016 Pheochromocytoma patients can rarely have prolonged QT interval in the ECG. We report three cases of pheochromocytoma in females presenting with ventricular arrhythmia; two had torsades de pointes and a third patient had frequent VPCs and nonsustained ...
Sai Satish Oruganti
doaj +1 more source
Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia
British Journal of Pharmacology, Volume 183, Issue 17, Page 5407-5420, September 2026.Background and Purpose Loss‐of‐function mutations of the voltage‐gated Kv7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT interval.
Jessica Jowais +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2834-2852, August 2026.Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval +6 more
wiley +1 more source
Sleep-Associated Torsades de Pointes: A Case Report
Clinical Practice and Cases in Emergency Medicine, 2017 Torsades de Pointes (TdP) is a polymorphic ventricular tachycardia that occurs in the presence of an acquired or congenital long QT syndrome (LQTS). We present the case of a 57 year-old man with end-stage renal disease on methadone maintenance in which ...
Guy Carmelli, Ian S. deSouza
doaj +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 387-393, August 2026.5‐hydroxytryptamine type 3 (5‐HT3) receptor antagonists are used to treat nausea and vomiting and in the prevention of chemotherapy‐induced, radiation‐induced, and postoperative nausea and vomiting. Most of the 5‐HT3 receptor antagonists (i.e., ondansetron, tropisetron, dolasetron, palonosetron, and ramosetron) are metabolized by CYP2D6, but the extent
Claire Moore +16 more
wiley +1 more source
Indian Pacing and Electrophysiology Journal, 2017 A 79-year-old woman who underwent catheter ablation for paroxysmal atrial fibrillation presented with Torsades de Pointes (TdP). Aggravation of prolonged QT interval which is most likely due to neural modulation by catheter ablation, played major role in
Yae Min Park +6 more
doaj +1 more source
QTc Interval Prolongation and Associated Drug Therapy in Hospitalized Older Adults
Journal of the American Geriatrics Society, EarlyView.
Francesco Fantin +7 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 8, August 2026.Network pharmacology combined with in vivo and in vitro experiments identified PI3K/AKT signaling as a candidate pathway associated with the protective effects of 10‐Gingerol (10Gin) against arsenic trioxide (ATO)‐induced cardiotoxicity. 10Gin improved myocardial histopathology and cardiac systolic function in ATO‐treated mice, while attenuating ...
Bin Zheng +7 more
wiley +1 more source