Results 51 to 60 of about 58,709,041 (128)

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Quizartinib Resistance Mutations and Treatment Outcomes in Relapsed or Refractory FLT3‐ITD–Positive AML

Cancer Science, EarlyView.
ABSTRACT Quizartinib is a FMS‐like tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 internal tandem duplication (FLT3‐ITD)–positive acute myeloid leukemia (AML). We aimed to evaluate quizartinib resistance mechanisms, in addition to efficacy and safety outcomes, in patients with relapsed or refractory FLT3‐ITD–positive AML.
Yuichiro Semba, Toshihiro Miyamoto, Senji Kasahara, Yoshikane Kikushige, Takahiro Maeda, Goichi Yoshimoto, Shuichi Ota, Akio Saito, Yuho Najima, Hiroki Hosoi, Daigo Niiya, Koji Kato, Koji Nagafuji, Takashi Akasaka, Tomohiko Kamimura, Atsushi Takita, Maiko Narahara, Tadashi Toki, Koichi Iwanaga, Koji Yonemoto, Mine Harada, Koichi Akashi   +21 more
wiley   +1 more source

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

Journal of Cardiovascular Electrophysiology, EarlyView.
The study examines 76 patients of the German multicenter study COGIA with suspected BrS in 12 centers in Germany. Thirty‐nine patients met the current ESC diagnostic criteria, 34 of whom met the Shanghai Score criteria. Four major arrhythmic events (ACA, SCD, appropriate ICD shock) occurred in the cohort (5.3%), all in the group of patients fulfilling ...
Lea Lippert, Tobias Burkard, Franziska Markel, Volker Debus, Fridrike Stute, Anna Kamphues, Robert Dalla Pozza, Stefan Rupp, Maria B. Gonzalez y Gonzalez, Claudia Junge, Majed Kanaan, Kirstin Hoff, Anja Hanser, Sven Dittmann, Dominik Sebastian Westphal, Isabel Diebold, Sebastian Clauß, Stefanie Kessner, Marc‐Phillip Hitz, Kolja Becker, Stefan Kääb, Peter Ewert, Michael Hofbeck, Wolfgang Wällisch, Sven Dittrich, Anselm Uebing, Stephan Neumann, Jan‐Hendrik Nürnberg, Joachim Hebe, Rainer Kozlik‐Feldmann, Philipp Beerbaum, Gunter Kerst, Eric Schulze‐Bahr, Roman Gebauer, Gabriele Hessling, Cordula Maria Wolf   +35 more
wiley   +1 more source

Amiodarone: Is it Safe in Stress Cardiomyopathy?

Indian Journal of Clinical Cardiology, 2023
Amiodarone is a broad-spectrum antiarrhythmic agent used in day-to-day practice to treat ventricular tachycardia (VT) and supraventricular tachycardias like atrial flutter/atrial fibrillation.
Manisha Sreeramdass, M. S. Aditya, T. Krishna Kumar   +2 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Extracellular ionic concentration modulates arrhythmias in a simulated population of human ventricular myocytes with long QT syndrome type 3

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustrating the in silico study pipeline. A total of 50,000 virtual myocytes were generated, which were then filtered to 7093 myocytes that fit experimentally constrained biomarkers for physiological electrical and calcium behaviour under wild‐type conditions.
Katherine Flannery, Jacob A. Miller, Steven Poelzing, Seth H. Weinberg   +3 more
wiley   +1 more source

Donepezil-induced torsades de pointes without QT prolongation [PDF]

, 2013
We report a case of torsades de pointes (TdP) induced by donepezil without QT prolongation. An 86-year-old woman was admitted to our hospital because of a syncopal attack. She had been treated for Alzheimer's disease with donepezil.
Akashi, Shintaro, Nakashima, Tadaaki, Shimizu, Akihiko, Ogawa, Hiroshi, Hadano, Yasuyuki, Miyazaki, Yosuke, 清水, 昭彦, Kimura, Masayasu, Mochizuki, Mamoru, Wakeyama, Takatoshi, Iwami, Takahiro   +10 more
core   +1 more source

Torsades de Pointes after Ondansetron Infusion in 2 Patients

, 2017
Drugs that prolong the electrocardiographic QT interval increase the risk of ventricular arrhythmias, particularly torsades de pointes. Ondansetron, a 5-hydroxytryptamine type 3 receptor antagonist antiemetic, is one such drug.
Sion K. Roy, Tri Trinh, Danny Y. Lee
core   +1 more source

The ultrarapid delayed rectifier potassium current has important functional role in the repolarization reserve of canine and human ventricular muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The ultrarapid delayed rectifier potassium current (IKur) has long been considered an atrial‐specific current with no functional role in the ventricles, despite evidence of its expression in ventricular myocytes. In the present study we challenged this prevailing concept and investigated the potential role of IKur in ventricular ...
Alaa Amin E. Abdelmagid, Aiman Saleh A. Mohammed, Gábor Mohácsi, Benjámin Paskuj, Gergő Bitay, Jakub Tomek, Sahil Dalal, Tamás Árpádffy‐Lovas, Vivien Demeter‐Haludka, István Koncz, Muhammad Naveed, László Virág, Norbert Nagy, András Varró, István Baczkó, Norbert Jost, Zsófia Kohajda, Leila Topal   +17 more
wiley   +1 more source

Iron Overload Leading to Torsades de Pointes in β-Thalassemia and Long QT Syndrome [PDF]

, 2016
The authors present a unique case of torsades de pointes in a β-thalassemia patient with early iron overload in the absence of any structural abnormalities as seen in hemochromatosis.
Schmitt, Nicole, Refaat, Marwan M., Scheinman, Melvin, Hotait, Mostafa, El Hage, Lea, Scheinman, Melvin M., Steffensen, Annette Buur, El-Hage, Lea, Refaat, Marwan M, Badhwar, Nitish   +9 more
core   +1 more source