Results 41 to 50 of about 466,154 (153)

Cardiovascular safety of testosterone therapy—Insights from the TRAVERSE trial and beyond: A position statement of the European Expert Panel for Testosterone Research

Andrology, EarlyView.
Abstract Introduction Testosterone therapy has become a cornerstone treatment for men with hypogonadism, offering significant benefits such as improved sexual function, mood, muscle mass, and bone density. However, concerns about its cardiovascular safety have historically tempered its use.
Michael Zitzmann, Giulia Rastrelli, Robert D Murray, David Edwards, Yacov Reisman, Preethi Mohan Rao, Alexander Sahi, Thomas Hugh Jones, Alberto Ferlin, Eleni Armeni, Emiliano Corpas, Jann‐Frederik Cremers, Janine David, Stefan Arver, Leen Antonio, Giovanni Corona   +15 more
wiley   +1 more source

Methadone, Metoclopramide and Metronidazole Interaction Causing Torsades de Pointes

Clinics and Practice, 2021
There are several classes of medications that can cause prolongation of the corrected QT (QTc) interval and potentially Torsades de Pointes (TdP). Most of these medications are commonly used in the emergency department, and interaction between these ...
Karthik Gnanapandithan, Nishrutha Karthik, Jaime Gerber   +2 more
doaj   +1 more source

Bradycardia and Other Arrhythmias in Patients With Hepatorenal Syndrome‐Acute Kidney Injury Following Terlipressin Treatment: A Pooled Analysis of Three North American Phase III Clinical Studies

Alimentary Pharmacology &Therapeutics, EarlyView.
In a pooled analysis, bradycardia was observed in 6% of terlipressin‐treated patients but rarely required a dose interruption or reduction. Arrhythmia serious adverse event incidences were low and similar in both treatment groups. Routine intensive cardiac monitoring for the detection of arrhythmias may not be necessary during terlipressin ...
Jasmohan S. Bajaj, Paul Kwo, Stephen Chris Pappas, Jacqueline G. O'Leary, Khurram Jamil, Sanaz Cardoza, Florence Wong   +6 more
wiley   +1 more source

Long QT Syndrome With Wolff-Parkinson-White Syndrome Resulting From a Novel Mutation in ANK2: A Case Report and Literature Review

Cardiology Discovery
. Congenital long QT syndrome (LQTS) is a life-threatening ion channelopathy caused by mutations in genes encoding specific ion channels, which can result in malignant arrhythmia of the torsades de pointes type.
Jian Li, Shixing Li, Chuang Zhang, Xiangmin Shi, Hanjia Gao   +4 more
doaj   +1 more source

QT Prolongation Complicated with Torsades de Pointes in Prosthetic Mitral Valve Endocarditis: A Case Report

Case Reports in Medicine, 2012
We present the case of a 49-year-old male patient with prosthetic mitral valve endocarditis associated with QT prolongation and torsades de pointes. He was asymptomatic until the end of January 2012, when he was admitted to our hospital emergency unit ...
A. Tounsi, L. Abid, M. Akrout, M. Hentati, S. Kammoun   +4 more
doaj   +1 more source

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

Cell Reports, 2018
Summary: To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 drugs ...
Ksenia Blinova, Qianyu Dang, Daniel Millard, Godfrey Smith, Jennifer Pierson, Liang Guo, Mathew Brock, Hua Rong Lu, Udo Kraushaar, Haoyu Zeng, Hong Shi, Xiaoyu Zhang, Kohei Sawada, Tomoharu Osada, Yasunari Kanda, Yuko Sekino, Li Pang, Tromondae K. Feaster, Ralf Kettenhofen, Norman Stockbridge, David G. Strauss, Gary Gintant   +21 more
doaj   +1 more source

Refractory Torsades de Pointes Due to Dofetilide Overdose

Journal of Investigative Medicine High Impact Case Reports, 2021
Dofetilide, a class III antiarrhythmic, is widely used in the treatment of cardiac arrhythmias. Antiarrhythmic drugs can have a long duration of action that prolongs the QT interval.
James Crosby DO, Huzefa Bhopalwala MD, Amrin Kharawala MD, Nakeya Dewaswala MD, Subramanya Shyam Ganti MD, MBBS, Adnan Bhopalwala MD   +5 more
doaj   +1 more source

The apicobasal dispersion of ventricular repolarization in humans is associated with age and affects arrhythmia vulnerability

The Journal of Physiology, EarlyView.
Abstract figure legend We investigated the age‐ and sex‐related differences in the apicobasal repolarization gradient (ABRG) and evaluated their possible role inventricular arrhythmia vulnerability. Electrocardiographic imaging (ECGI) was performed in healthy subjects during sinus rhythm, and the average recovery time (RT) and activation–recovery ...
Vladimír Sobota, Job Stoks, Kiran Haresh Kumar Patel, Roshni Shetty, Haibo Ni, Eleonora Grandi, Fu Siong Ng, Paul G. A. Volders, Matthijs J. M. Cluitmans, Jason D. Bayer   +9 more
wiley   +1 more source

Trends in drug–drug interaction prevalence and longitudinal associations with health outcomes in the older community‐dwelling population: Findings from The Irish LongituDinal study on Ageing

British Journal of Clinical Pharmacology, Volume 91, Issue 11, Page 3244-3256, November 2025.
Aims We estimate trends in severe drug–drug interaction (DDI) prevalence and examine longitudinal associations between DDI exposure and health outcomes (emergency department [ED] visits, quality‐of‐life [QoL] and functional decline) over approximately 10‐years in the older community‐dwelling population in Ireland.
John E. Hughes, Caitriona Cahir, Kathleen E. Bennett   +2 more
wiley   +1 more source

When the U Wave Tells the Story: Andersen–Tawil Syndrome Unmasked

Annals of Noninvasive Electrocardiology, Volume 30, Issue 6, November 2025.
Recurrent syncope in a young woman was diagnosed as Andersen‐Tawil syndrome (ATS), characterized by prominent U waves and prolonged QTU intervals. Genetic testing confirmed a KCNJ2 mutation. Tailored treatment, including medication adjustments, led to symptom improvement, emphasizing the importance of accurate diagnosis and management in ATS.
Shasha Yu, Hang Lv
wiley   +1 more source