Results 51 to 60 of about 29,835 (313)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Coronal alignment does not enable to predict the degree of femoral and tibial torsion
Journal of Experimental OrthopaedicsPurpose Malalignment of the lower extremity can affect one, two or all three anatomic planes. We hypothesized an influence between the malalignment of the coronal and axial planes.
Leonard Grünwald +4 more
doaj +1 more source
The Impact of Metal Inert Gas Welding on the Corrosion and Mechanical behavior of AA 6061 T6
International Journal of Electrochemical Science, 2014 An attempt has been made to investigate the effects of MIG welding on the corrosion and mechanical properties of AA 6061 T6. A series of experimental techniques has been conducted to evaluate the corrosion and mechanical properties of the alloy.
E. Mahdi, E.O. Eltai, A. Rauf
doaj +1 more source
Microstructure and mechanical properties at different length scales and strain rates of nanocrystalline tantalum produced by high-pressure torsion [PDF]
, 2011 Fully dense, nanocrystalline tantalum (average grain size as small as similar to 40 nm) has been processed for the first time by high-pressure torsion. High-resolution transmission electron microscopy reveals non-equilibrium grain boundaries and grains ...
Kecskes LJ +6 more
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
An Experimental Study of Torsional Properties of Polyvinylchloride
Kurdistan Journal of Applied Research, 2017 In this research, an experimental study has been performed to investigate the mechanical properties through torsion testing of polyvinylchloride (PVC) polymer specimens.
Sarkawt Rostam +4 more
doaj +1 more source
Topological state transfer in Kresling origami
Communications Materials, 2022 Topological mechanical metamaterials have been considered effective for energy manipulation via edge states, but manipulating these states remains challenging.
Yasuhiro Miyazawa +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Torsional Mechanics of DNA Are Regulated by Small-Molecule Intercalation
The Journal of Physical Chemistry B, 2010 Whether the bend and twist mechanics of DNA molecules are coupled is unclear. Here, we report the direct measurement of the resistive torque of single DNA molecules to study the effect of ethidium bromide (EtBr) intercalation and pulling force on DNA twist mechanics.
Celedon, Alfredo +2 more
openaire +5 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source