Results 131 to 140 of about 688,578 (316)

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

High serum total cholesterol; an indicator for monitoring cholesterol lowering efforts : U.S. adults, 2005-2006 [PDF]

"Elevated serum total cholesterol is a major and modifiable risk factor for heart disease, the lead-ing cause of death in the United States (1,2).

core  

Association between variations in the gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol-6

, 2011
Oncentrations of patients with at least one copy of the minor allele.Copyright information:Taken from "Association between variations in the gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol"http://www ...
Christian Herder (44905), Thomas Illig (44906), Melanie Kolz (44899), Martina Müller (44900), Natalie Khuseyinova (44901), Christine Meisinger (44904), Barbara Thorand (44903), Jens Baumert (39941), Wolfgang Koenig (26222), Norman Klopp (44902)   +9 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Association between variations in the gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol-3

, 2011
Xis indicate TC/HDL-C concentrations of patients with at least one copy of the minor allele.Copyright information:Taken from "Association between variations in the gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL ...
Christian Herder (44905), Thomas Illig (44906), Melanie Kolz (44899), Martina Müller (44900), Natalie Khuseyinova (44901), Christine Meisinger (44904), Barbara Thorand (44903), Jens Baumert (39941), Wolfgang Koenig (26222), Norman Klopp (44902)   +9 more
core   +1 more source

Association of Plasma Lipids with White Matter Hyperintensities in Patients with Acute Ischemic Stroke

International Journal of General Medicine, 2023
Yongkang Liu,1 Cuiping Yuan,1 Xiao Chen,1 Xiaokun Fang,1 Jingru Hao,1 Maodong Zhou,1 Xin Sun,1 Minghua Wu,2 Zhongqiu Wang1 1Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, People’s Republic of ...
Liu Y, Yuan C, Chen X, Fang X, Hao J, Zhou M, Sun X, Wu M, Wang Z   +8 more
doaj  

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Association between variations in the gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol-10

, 2011
Is indicate TC/HDL-C concentrations of patients with at least one copy of the minor allele.Copyright information:Taken from "Association between variations in the gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL ...
Christian Herder (44905), Thomas Illig (44906), Melanie Kolz (44899), Martina Müller (44900), Natalie Khuseyinova (44901), Christine Meisinger (44904), Barbara Thorand (44903), Jens Baumert (39941), Wolfgang Koenig (26222), Norman Klopp (44902)   +9 more
core   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Preparation and some properties of cholesterol oxidase from Rhodococcus sp. R14-2

, 2008
Rhodococcus sp. R14-2, isolated from Chinese Jin-hua ham, produces a novel extracellular cholesterol oxidase (COX). The enzyme was extracted from fermentation broth and purified 53.1-fold based on specific activity.
Wang, C.T., Ji, B.P., Nout, M.J.R., Cao, Y.P., Wang, J., Sun, B.G., Zhao, Y.H.   +6 more
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