Results 141 to 150 of about 7,360,049 (312)
Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency
Advanced Materials, EarlyView.As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang +12 more
wiley +1 more source
Total Cholesterol and Blood Sugar Levels in Type 2 Diabetes Mellitus Patients [PDF]
Diabetes Mellitus is a syndrome characterized by high blood sugar levels and various metabolic disorders caused by hormonal imbalance. The aim of this study was to determine the relationship between total cholesterol levels in type 2 diabetes mellitus ...
Slamet WARDOYO +6 more
core +2 more sources
Advanced Materials, EarlyView.Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol +16 more
wiley +1 more source
Total and high-density lipoprotein cholesterol in adults; National Health and Nutrition Examination Survey, 2009-2010 [PDF]
The percentage of adults aged 20 and over with high total cholesterol has declined substantially since 1999\u20132000. For 2009\u20132010, the percentage of adults with high total cholesterol was 13.4%, thus meeting the Healthy People 2010 target of 17 ...
core
Advanced Materials Interfaces, EarlyView.This review discusses recent progress in metal complex‐based, non‐enzymatic electrochemical sensors for cholesterol detection. We examine metal oxides, metal sulfides, and hybrid nanomaterials, highlighting their catalytic mechanisms and material design strategies.
Longfei (Jack) Yin +6 more
wiley +1 more source
Total and High-Density Lipoprotein Cholesterol in Adults: United States, August 2021- August 2023 [PDF]
This report presents prevalence of high total cholesterol and low high-density lipoprotein cholesterol by sex and age group for adults age 20 and older from the August 2021\u2013August 2023 National Health and Nutrition Examination ...
core
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source
Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis
Advanced Science, EarlyView.Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang +9 more
wiley +1 more source
Total Cholesterol and Cholesterol species determination
Protocol Exchange, 2011 Wei Zou, Wei Zou
openaire +1 more source
Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis
Advanced Science, EarlyView.Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu +17 more
wiley +1 more source