Results 151 to 160 of about 7,735,886 (346)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Automating Registry Data Collection of Total Ankle Arthroplasty Complications Using Artificial Intelligence: A Pilot Study

open access: yesFoot & Ankle Orthopaedics
Research Type: Level 3 - Retrospective cohort study, Case-control study, Meta-analysis of Level 3 studies Introduction/Purpose: Identifying and tracking surgical complications is a critical component of maintaining quality registries and improving ...
Michael Hewitt BA   +7 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

A Qualitative Study of Discharge Waste Water from Babil / 2 Batteries Factory in Baghdad

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences, 2017
 The quality of industrial water from (Babil / 2 batteries factory in Baghdad) was  investigated, and evaluated the physical and chemical characteristics of the water discharged from sections ALShahen , final collection sank. The values were represented
Suhair A. Musa, Manal M.AL-Musawi
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Collective Total Synthesis of Secologanin-Related Natural Products

open access: yes
AbstractWe have been interested in the reactivity of secologanin, which is transformed into more than 3000 natural products in nature and have been working on the bioinspired synthesis of several natural products using secologanin derivatives. In this chapter, we describe the total synthesis of secologanin using an organocatalytic reaction and the ...
Jukiya Sakamoto, Hayato Ishikawa
openaire   +1 more source

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