Results 261 to 270 of about 7,735,886 (346)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A tale of two management programs: Insights from a state-line wildlife disease outbreak. [PDF]

PNAS Nexus
Whetten AB, Hefley TJ, Jacques CN, Storm DJ, Walsh DP.   +4 more
europepmc   +1 more source

Brian Aldiss, La Tour des damnés (Total environment), Neuvy-en-Champagne, Le Passager clandestin, collection « Dyschroniques » n° 2, 2013 (édition originale en 1968, première édition en français en 1968), 112 pages, 8 €

, 2013
dissidences
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Association between dietary protein intake and preterm birth in pregnant women with gestational diabetes mellitus: the WeBirth cohort study. [PDF]

Asia Pac J Clin Nutr
Shi M, Miao Z, Yin Y, Ye M, Wang X, Lu S, Wu Y, Fu Y, Hu W.   +8 more
europepmc   +1 more source

Digestibility by Lambs of Water-Stressed Alfalfa as Determined by Total Collection or Internal Markers

, 1987
D. J. Undersander, N. A. Cole, C. H. Naylor   +2 more
openalex   +1 more source

Collective Asymmetric Total Syntheses of Musellarins A–E

The Journal of Organic Chemistry
Yichen Liu, Yanghui Ou, Vincent Chang, Hongliang Yao, Rongbiao Tong   +4 more
openaire   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Transmission status of lymphatic filariasis in hotspots of filarial infection, persistent districts of nepal during post-MDA surveillance. [PDF]

PLoS One
Mehta PK, Maharjan M.
europepmc   +1 more source

Privacy: Total Information Awareness Programs and Related Information Access, Collection and Protection Laws

, 2013
Gina Marie Stevens
openalex   +1 more source