Results 151 to 160 of about 43,554 (293)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

An efficient algorithm for exploring RNA branching conformations under the nearest-neighbor thermodynamic model. [PDF]

Algorithms Mol Biol
Poznanović S, Cardwell O, Heitsch C.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Exploring the properties of benzenoid hydrocarbons through QSPR modeling and domination-based energy parameters. [PDF]

Sci Rep
Sankaran S, Chidambaram N.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Assessing data size requirements for training generalizable sequence-based TCR specificity models via pan-allelic MHC-I point-mutation ligandome evaluation. [PDF]

Sci Rep
Delaunay A, McGibbon M, Djermani B, Gorbushin N, Chaves García-Mascaraque S, Rayment I, Kizhvatov I, Petit C, Lang M, Beguir K, Sahin U, Copoiu L, Lopez Carranza N, Tovchigrechko A.   +13 more
europepmc   +1 more source

Progress towards the two-thirds conjecture on locating-total dominating sets

We study upper bounds on the size of optimum locating-total dominating sets in graphs. A set $S$ of vertices of a graph $G$ is a locating-total dominating set if every vertex of $G$ has a neighbor in $S$, and if any two vertices outside $S$ have distinct
Chakraborty, Dipayan, Hakanen, Anni, Henning, Michael, Foucaud, Florent, Wagler, Annegret, Henning, Michael A., Wagler, Annegret K.   +6 more
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

TGN-MCDS: A Temporal Graph Network-Based Algorithm for Cluster-Head Optimization in Large-Scale FANETs. [PDF]

Sensors (Basel)
Fan X, Yang Y, Zhang S, Cai W.
europepmc   +1 more source