Results 81 to 90 of about 1,149,119 (338)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Imaging ionospheric inhomogeneities using spaceborne synthetic aperture radar [PDF]

, 2011
We present a technique and results of 2-D imaging of Faraday rotation and total electron content using spaceborne L band polarimetric synthetic aperture radar (PolSAR).
Chapman, B., Freeman, A., Li, Z., Pi, X., Rosen, P.   +4 more
core   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Full-Potential LMTO: Total Energy and Force Calculations [PDF]

, 1999
The essential features of a full potential electronic structure method using Linear Muffin-Tin Orbitals (LMTOs) are presented. The electron density and potential in the this method are represented with no inherent geometrical approximation.
Alouani, Mebarek, Eriksson, Olle, Price, David L., Wills, John M   +3 more
core  

Peak characteristics of F2 region over Tucumán: Predictions and measurements [PDF]

, 2008
Ionosonde measurements obtained at Tucuman are used to check the validity of the International Reference Ionosphere model to predict the maximum electron density of F2 region (NmF2) and its height (hmF2) over this station. Data corresponding to different
Ezquer, Rodolfo Gerardo, López, J., Mosert, Marta Estela, Scida, Luis Alberto   +3 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Long Term Global Ionospheric Total Electron Content Trend Analysis

Geophysical Research Letters
Simulations based on physical models of the thermosphere‐ionosphere system suggest that the ionosphere will sink as the thermosphere cools and contracts in response to increasing greenhouse gas concentrations.
M. Paula Natali, Anabella Urutti, Juan Manuel Castaño, Brunos S. Zossi, Trinidad Duran, Amalia Meza, Ana G. Elias   +6 more
doaj   +1 more source

Statistical Analysis of Ionospheric Total Electron Content (TEC): Long-Term Estimation of Extreme TEC in Japan [PDF]

, 2020
Michi Nishioka, Susumu Saito, Chihiro Tao, Daikou Shiota, Takuya Tsugawa, Mamoru Ishii   +5 more
openalex   +1 more source

Effects of Ionospheric Asymmetry on Electron Density Standard Inversion Algorithm Applicable to Radio Occultation (RO) Data Using Best-suited Ionospheric Model [PDF]

, 2013
The "Onion-peeling" algorithm is a very common technique used to invert Radio Occultation (RO) data in the ionosphere. Because of the implicit assumption of spherical symmetry for the electron density (Ne) distribution in the ionosphere, the standard ...
Kos, T., Najman, P., Notarpietro, Riccardo, Shaikh, Muhammad Mubasshir   +3 more
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source