Results 131 to 140 of about 13,562,066 (260)

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Mass balance, excretion, and pharmacokinetics of a single oral dose of [¹⁴C]pixavir marboxil in healthy Chinese male participants. [PDF]

Front Pharmacol
Zhao C, Yang Y, Liu G, Qian L, Liu Y, Tsai CY, Chang LW, Chen Q, Qian H, Jia J, Liu Y.   +10 more
europepmc   +1 more source

Vince Colosimo Collection

Vince Colosimo is an Australian actor who has worked in theatre, film and television. Colosimo has made a number of television appearances, including A Country Practice, Stingers, Something in the Air and The Secret Life of Us.

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Collection Collective

, 2017
Collection Collective is a contemporary art collection instituted, owned and managed collectively by its members. The project was initiated by Angel, Morariu and Voinea as a speculative curatorial proposal, which aimed to question critically private ...
Collection Collective Members, Angel, J., Morariu, V., Voinea, R.   +3 more
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Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Gut microbiota-driven indole-3-propionic acid and kynurenine production is associated with improved metabolic adaptation in periparturient dairy cows. [PDF]

J Anim Sci Biotechnol
Liu X, Yang Z, Zhang X, Tang W, Wang Y, Cao Z, Yang H, Wang W, Hao Y, Li S.   +9 more
europepmc   +1 more source

Pedagogically Annotated Collection

The collection creates links between Earth system resources and related pedagogical resources. The pedagogical resources focus on misconceptions or preconceptions commonly encountered while teaching an Earth system topic; skills needed for completing an ...

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Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Absorption, distribution, metabolism, and excretion of [¹⁴C]SH-1028, a third-generation <i>EGFR</i>-TKI, in rats and humans. [PDF]

Front Pharmacol
Zhou S, Wu Y, Liu W, Zhou C, Xie L, Zhuang Q, Wang L, Chen J, Zhu B, Zhang C, Zhang X, Shao F.   +11 more
europepmc   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source