Results 121 to 130 of about 249,430 (314)

Managing Opioid-Tolerant Patients in the Perioperative Surgical Home. [PDF]

, 2016
Management of acute postoperative pain is important to decrease perioperative morbidity and improve patient satisfaction. Opioids are associated with potential adverse events that may lead to significant risk.
Baratta, Jaime L., Schwenk, Eric S., Viscusi, Eugene R., Wenzel, John T.   +3 more
core   +3 more sources

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Continuous infusion of propofol at variable rates in a time dependent in cats

Semina: Ciências Agrárias, 2015
Felines biotransforms propofol slowly developing cumulative effect. The aim this study was to develop a scheme of continuous infusion of propofol at time dependent variable rate in cats.
Felipe Comassetto, Martielo Ivan Gehrcke , Marcos Paulo Antunes de Lima , Ronise Tocheto , Nilson Oleskovicz   +4 more
doaj   +1 more source

Designing the ideal perioperative pain management plan starts with multimodal analgesia. [PDF]

, 2018
Multimodal analgesia is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while reducing individual class-related side effects ...
Mariano, Edward R., Schwenk, Eric S.
core   +1 more source

A Possible Case of Neurogenic Pulmonary Edema in a Sheep following Intracranial Surgery [PDF]

, 2016
A 3-year-old female crossbred sheep weighing 64 kg was anaesthetized for intracranial surgery as a part of a research project. Premedication and induction of anesthesia were uneventful as well as tracheal intubation.
Adami, C, Casoni, D, Giovannini, A E J, Precht, C M   +3 more
core   +2 more sources

Wearable Systems of Reconfigurable Microneedle Electrode Array for Subcutaneous Multiplexed Recording of Myoelectric and Electrochemical Signals

Advanced Science, EarlyView.
A reconfigurable microneedle electrode array integrated system is developed for minimally invasive and transdermal monitoring of subcutaneous electromyography, reactive oxygen species, and pH values. By assembling discrete thumbtack‐shaped microneedles into an array, the system enables multi‐parameter detection with single‐microneedle resolution.
Zhengjie Liu, Chuanjie Yao, Xingyuan Xu, Xinshuo Huang, Shuang Huang, Shantao Zheng, Tao Zhang, Yan Li, Fanmao Liu, Yuxiang Wu, Jing Liu, Hui‐jiuan Chen, Xi Xie   +12 more
wiley   +1 more source

Multi-Agent Deep Reinforcement Learning for Multiple Anesthetics Collaborative Control [PDF]

arXiv
Automated control of personalized multiple anesthetics in clinical Total Intravenous Anesthesia (TIVA) is crucial yet challenging. Current systems, including target-controlled infusion (TCI) and closed-loop systems, either rely on relatively static pharmacokinetic/pharmacodynamic (PK/PD) models or focus on single anesthetic control, limiting ...
arxiv  

The uncertain surgery time in integrated sequencing, planning and scheduling problem of the surgical ward [PDF]

arXiv, 2019
The surgical department and adequate access to health care are critical problems. The operating room plays a fundamental role in the performance of a hospital. The real problem faces several issues to collect data and optimize scheduling and planning. In this paper, the planning and integral scheduling problems were taken into consideration including ...
arxiv  

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]

, 2013
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Arai, Ken, Cianchetti, Flor A., Fan, Xiang, Förch, Christian, Lauer, Arne, Leyen, Klaus van, Lo, Eng H., Mandeville, Emiri, Rosidi, Nathanael L., Schaffer, Chris B., Schlunk, Frieder, Steinmetz, Helmuth, Wang, Xiaoying, Yigitkanli, Kazim   +13 more
core   +3 more sources

Oral Microalgae‐Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study presents an innovative oral microalgae‐based biosystem to inhibit tumor growth, reduce PD‐1 expression, and activate immune responses of hepatocellular carcinoma. When combined with enhanced irreversible electroporation treatment, it demonstrates a synergistic effect that effectively reduces the tumor burden and enhances the tumor immune ...
Cheng Zeng, Shiyuan Hua, Jiayu Zhou, Tangye Zeng, Jianke Chen, Lijian Su, Angfeng Jiang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source