Results 131 to 140 of about 160,656 (308)
Advanced Science, EarlyView.Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee +9 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang +13 more
wiley +1 more source
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
Advanced Science, EarlyView.CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
Clinical evaluation of repeated propofol total intravenous anesthesia in dog [PDF]
, 2008 This current study designed to evaluate any possible changes in required doses and other cardiopulmonary findings after repeated propofol total intravenous anesthesia (TIVA) in dog.
Akhlaghi, Mreza. +4 more
core
Prospect of Propofol-Total Intravenous Anesthesia
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA, 2007 弘前大学医学部附属病院では, 全身麻酔管理の80%以上にプロポフォールを主体にケタミンやフェンタニルを加えた全静脈麻酔法 (TIVA) を用いて施行している. TIVAにより, 地球温暖化やオゾン層破壊の原因となる亜酸化窒素や揮発性吸入麻酔薬の使用を減らすことができる. また, 現在までの研究報告をみると揮発性吸入麻酔薬が炎症促進作用を示すのに対し, 静脈麻酔薬プロポフォール, ケタミンは抗炎症効果を示す可能性が高い. また, プロポフォールにがん転移抑制効果があるのに対し, 揮発性吸入麻酔薬では転移を促進させるとする論文も発表されている. したがって, 環境に優しく侵襲防御に有利なプロポフォールを中心としたTIVAは, 今後さらに普及していくものと予測される.
openaire +2 more sources
Advanced Science, EarlyView.Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider +20 more
wiley +1 more source
Advanced Science, EarlyView.Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu +11 more
wiley +1 more source
Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy
Advanced Science, EarlyView.Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih +12 more
wiley +1 more source
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source