Results 51 to 60 of about 262,213 (318)

Outcomes of the rotating hinge knee in revision total knee arthroplasty with a median follow-up of 6.2 years [PDF]

open access: gold, 2021
Jake von Hintze   +4 more
openalex   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

open access: yesAdvanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng   +15 more
wiley   +1 more source

Distal femoral morphology as a risk factor for osteoarthritis

open access: yesThe Anatomical Record, EarlyView.
Abstract Osteoarthritis (OA) is a leading cause of disability affecting millions of adults in the United States, commonly resulting in the need for total knee arthroplasty (TKA) to restore mobility and quality of life. This study investigates potential differences in baseline distal femoral shape between individuals who received TKA due to OA and a ...
Haley Horbaly
wiley   +1 more source

Rehabilitation Interventions Delivered via Telehealth to Support Self‐Management of Rheumatic and Musculoskeletal Disease: A Scoping Review

open access: yesArthritis &Rheumatology, EarlyView.
Objective To identify and summarize existing telerehabilitation interventions for people living with rheumatic and musculoskeletal diseases (RMDs), including the rehabilitation components, the technology used, the type of health care professional (HCP) interaction, and how the effectiveness is evaluated.
Thomas A. Ingram   +5 more
wiley   +1 more source

The Warwick patellofemoral arthroplasty trial: a randomised clinical trial of total knee arthroplasty versus patellofemoral arthroplasty in patients with severe arthritis of the patellofemoral joint

open access: yesBMC Musculoskeletal Disorders, 2011
Background Severe arthritis of the knee is a disabling condition, with over 50,000 knee replacements performed each year in the UK. Isolated patellofemoral joint arthritis occurs in over 10% of these patients with the treatment options being ...
Odumenya Michelle   +5 more
doaj   +1 more source

Image-based robot assisted bicompartmental knee arthroplasty versus total knee arthroplasty

open access: yesSICOT-J, 2022
Objective: To evaluate the short-term clinical outcomes of image-based robot-assisted bicruciate retaining bicompartmental knee arthroplasty and compare it to robot-assisted total knee arthroplasty in the Indian population. Methods: Between December 2018
Thilak Jai   +3 more
doaj   +1 more source

Prior osteosynthesis—unlike osteotomy—raises revision risk after total knee arthroplasty, predominantly via periprosthetic infection [PDF]

open access: hybridKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Previous knee surgery is discussed as a risk factor for total knee arthroplasty (TKA), yet most reports do not distinguish between osteotomy and osteosynthesis. The German Operationen‐ und Prozedurenschlüssel (OPS)‐based classification was used to compare the impact of these procedures on implant survival, mortality and complications ...
Nele Wagener   +4 more
openalex   +2 more sources

Monocyte‐Derived Macrophages‐Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Osteoarthritis (OA) is a debilitating joint disease that is characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet   +18 more
wiley   +1 more source

Micellar Liquid Chromatography Determination of Edoxaban in Oral Solid Dosage Forms: Theoretical Aspects and Validation

open access: yesChemMedChem, EarlyView.
A method is developed and validated to quantify edoxaban in solid oral dosage forms using micellar liquid chromatography. A chemometric strategy is used to study the retention mechanism. The procedure is green, economic, safe, and easy to handle; offers high sample throughput; and is reliable, thus useful for pharmaceutical quality control.
Juan Peris‐Vicente   +4 more
wiley   +1 more source

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