Results 91 to 100 of about 8,808,141 (242)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Identification of the Fractional-Order Systems: A Frequency Domain Approach [PDF]

Acta Montanistica Slovaca, 2011
The paper deals with a comparison of different optimization methods to identification of fractional order dynamical systems.The fractional models of the examples of physical systems - ultracapacitors - are established.
Andrzej Dzieliński, Dominik Sierociuk, Grzegorz Sarwas, Ivo Petráš,, Igor Podlubny, Tomáš Škovránek   +5 more
doaj  

The Improvement Based on the DV-Hop Localization Algorithm for Wireless Sensor Networks

Journal of Harbin University of Science and Technology, 2018
As the problems of lower localization accuracy appeared in the traditional DV-Hop algorithm，the author analyzed three main factors that influence the localization accuracy of original DV-Hop algorithm which started from the calculation of the average ...
DONG Jing-wei, YANG Guang, LIU Yang, Zhang Tian-qi   +3 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

An adapted version of the element-wise weighted total least squares method for applications in chemometrics

, 2007
The Maximum Likelihood PCA (MLPCA) method has been devised in chemometrics as a generalization of the well-known PCA method in order to derive consistent estimators in the presence of errors with known error distribution.
Markovsky, Ivan, Schuermans, Mieke, Van Huffel, Sabine   +2 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Deformation analysis by an improved similarity transformation

Applied Computing and Geosciences
In this contribution, deformation analysis is rigorously performed by a non-linear 3-D similarity transformation. In contrast to traditional methods based on linear least-squares (LLS), here we solve a non-linear problem without any linearization.
Vahid Mahboub
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Application of structured total least squares for system identification and model reduction

, 2004
The following identification problem is considered: minimize the l2 norm of the difference between a given time series and an approximating one under the constraint that the approximating time series is a trajectory of a linear time invariant system of a
Pintelon, R., Van Huffel, S., Willems, J. C., Rik Pintelon, Ivan Markovsky, Jan C. Willems, Markovsky, I., Bart De Moor, Sabine Van Huffel, De Moor, B.   +9 more
core