Results 81 to 90 of about 1,514,703 (285)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Linear-regression models and algorithms based on the Total-Least-Squares principle
Geodesy and Geodynamics, 2012 In classical regression analysis, the error of independent variable is usually not taken into account in regression analysis. This paper presents two solution methods for the case that both the independent and the dependent variables have errors.
Ding Shijun, Jiang Weiping, Shen Zhijuan
doaj +1 more source
An analysis of the mixed least squares-total least squares problems
Filomat, 2022 In this paper, we first get further consideration of the first order perturbation with normwise condition number of the MTLS problem. For easy estimation, we show a lower bound for the normwise condition number which is proved to be optimal. In order to overcome the problems encountered in calculating the normwise condition number, we give ...
openaire +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
On a Problem of Weighted Low-Rank Approximation of Matrices
, 2017 We study a weighted low rank approximation that is inspired by a problem of constrained low rank approximation of matrices as initiated by the work of Golub, Hoffman, and Stewart (Linear Algebra and Its Applications, 88-89(1987), 317-327).
Dutta, Aritra, Li, Xin
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
An improved mixed total least squares method for strain inversion from distance changes
Geodesy and Geodynamics, 2016 Based on the deficiency of the traditional total least squares method (TLS) in the field of geodetic inversion, the mixed error characteristics of the errors in variables (EIV) model were analyzed by considering the distance azimuth measurement error in ...
Zhiping Liu, Sida Li, Hefang Bian
doaj +1 more source