Results 41 to 50 of about 214,319 (261)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Zn situation of vegetable garden soils and its relation to soil organic carbon

浙江大学学报. 农业与生命科学版, 2000
With a field survey, Zn situation of vegetable garden soils and its relation to soil organic carbon were investigated. The results presented that the total Zn contents of vegetable garden soils in the survey area range 75.5-302.0 mg/kg with an average as
NI Wu-zhong, LONG Xin-xian, SUN Qin, HE Ji-xiu, YABG Xiao-e   +4 more
doaj   +1 more source

Carbon burial potential of the surface sediment and its associated anthropogenic impacts in the semi-closed area of Bohai Bay

Ecological Indicators, 2023
Carbon burial potential in marine sediments plays an important role in global warming. However, they are easily disturbed by human activities in coastal areas.
Yan Zhang, Ziyu Meng, Weijie Xu, Man Chai, Xiaoning Zhang, Hui Zeng, Lina Sun, Jiangang Jing, Fude Liu   +8 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Quantification of the Carbon Content of the Fractions of Humic Substances and Total Organic Carbon in Different Production Systems

Journal of Agricultural Science, 2017
Soil organic matter is degraded and easily altered by the type of management. The objective of this work is to determine the total organic carbon and humic substance fractions in the organic matter of the soil with different management types and depths in the western region of Paraná, Brazil. The work was carried out in the Experimental Farm “Professor
Carlos Augusto Rocha de Moraes Rego, Jonas Francisco Egewarth, Marcio André Francziskowski, Felipe Eliazar Cremonez, Paulo Sérgio Rabello de Oliveira, Maria Do Carmo Lana, Bruna Penha Costa, Eloisa Mattei, Marinês Carpiski Sampaio, Vanessa Aline Egewarth, Juan López De Herrera   +10 more
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The effect of litter layer structure on soil organic carbon

Ecological Indicators
Soil carbon pools constitute the world's largest terrestrial carbon storage system. The litter layer serves as a major source of soil organic carbon, and its components (such as broadleaf and coniferous leaves, as well as branches) are influenced by ...
Hong Lou, Anran Sheng, PhD, Fangfang Zhu, PhD, Yuchen Li, Yuyang Cao, Xiaoyi Hao, Yangui Qiao   +6 more
doaj   +1 more source