Results 61 to 70 of about 776,685 (306)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2008 International audienceThe Total Organic Carbon (TOC) content of the Gargasian strata studied in their historical stratotype area is rather low (0.3% on average). Only a few levels show TOC values approaching 1.2%.
Baudin, François +2 more
core +2 more sources
Comparison of indices for the prediction of nitrogen mineralization after destruction of managed grassland [PDF]
, 2010 Intensively managed grasslands are occasionally chemically killed with herbicide and ploughed in order to grow an arable crop. After this management, large N mineralization rates with large losses to the environment are commonly observed.
Smit, A., Velthof, G.L.
core +2 more sources
Total Organic Carbon and Total Nitrogen Contents in Lake Sediment as a Proxies of Paleoclimate
The Quaternary Research (Daiyonki-Kenkyu), 2003 湖沼堆積物中の全有機炭素(TOC)・全窒素(TN)含有率に関連する最近の研究を概観した.TOCおよびTNには,湖水中で自生するものと,陸上から運び込まれる外来性のものがあり,通常の調和型湖沼では前者を起源とするものが優占する.木崎湖における最近の研究では,1983年から1999年にかけての湖底堆積物中のTOC含有率は,同じ期間の湖水中の年間クロロフィルa量および冬の平均気温(12月～翌3月の平均)との間によい相関があることが認められた.このことは,気温が湖水中の生物生産性に影響を与えることを通じて,湖沼堆積物中への有機物流入を支配していることを意味する.野尻湖底堆積物のコア試料中のTOCとTNの含有率およびC/Nの変動を過去4.5万年間にわたって解析したところ ...
openaire +2 more sources
INTERPRETING 14C AGES OF THE TOTAL ORGANIC CARBON CONTENT OF PREHISTORIC POTTERY
Радиоуглерод в археологии и палеоэкологии: прошлое, настоящее, будущее. Материалы международной конференции, посвященной 80-летию старшего научного сотрудника ИИМК РАН, кандидата химических наук Ганны Ивановны Зайцевой, 2020 Археологическая хронология для некоторых археологических памятников Восточной Европы основана в основ- ном на прямом керамики. Даты по пищевому нагару на сосудах также были получены, если это было возможно, но гораздо больше 14C датировок было получено по общего содержания органического углерода (TOCC) в че- репках.
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Near infrared spectroscopy for predicting quality indices in the organic fertiliser industry [PDF]
, 2007 The carbon to nitrogen (C/N) ratio can provide information on the capacity of an organic input to be transformed into humus [1 - 3], but it is not sufficient in some cases [4].
Bastianelli, Denis +4 more
core
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Cumulative Effect of the Application of N and P Fertilizers on Soil Total and Labile Concentrations After 12 Cereal Crops on a Black Vertosol [PDF]
, 2001 Soil organic carbon is commonly used as a key indicator of sustainability of farming systems due to effects on nutrient availability, structural stability and its central role in soil biotic processes.
Birch, C. J. +3 more
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source