Results 91 to 100 of about 866,043 (269)

Effects of profile variability on aerodynamic performance of supersonic compressor cascade

Zhongguo Jianchuan Yanjiu
ObjectivesThis study seeks to evaluate the effects of profile variability on the aerodynamic per-formance of a compressor and provide guidance for the robust design of compressor blades.
Zhuoyuan CHEN, Shaojuan GENG, Shuaipeng LIU, Jiahao LIU, Hailong LIU   +4 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Optimization strategies for the design of pre-cooler based on the synergistic air-breathing rocket engine

Case Studies in Thermal Engineering
A foundation for the engineering of pre-coolers is provided to understand the flow and heat transfer characteristics of air pre-coolers. Using the pre-cooler in the combustor of the Synergistic Air-Breathing Rocket Engine (SABRE) as the research object ...
Zhaohui Yao, Yanming Liu, Weimin Bao, Wei Cheng, Xin Wei, Wen Bao   +5 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

THERMODYNAMIC ANALYSIS OF DIFFERENT WORKING FLUIDS USED IN ORGANIC RANKINE CYCLE FOR RECOVERING WASTE HEAT FROM GT-MHR [PDF]

Journal of Engineering Science and Technology, 2016
In this paper, the performance of 13 working fluids in two Organic Rankine Cycles, which operate as the bottoming cycles for recovering waste heat from gas turbine modular helium reactor (GT-MHR), is investigated.
AMIN HABIBZADEH, MOHAMMAD MEHDI RASHIDI
doaj  

Study on the Effect of Total Pressure Loss by Bell Mouth Inlet Screen

Journal of the Korean Society of Propulsion Engineers, 2021
Changwook Lee, Seong Man Choi
openaire   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Effect of Compressor Root Slot Structure on Suppressing Corner Separation and Aerodynamic Parameter Deterioration Induced by Seal Cavity Leakage Flow

Aerospace
To alleviate the adverse effects of the flow-field structure caused by interstage sealing structures on the aerodynamic characteristics of compressor cascades, a blade-root through-slot structure was designed in this study.
Wenfeng Xu, Xinrui Du, Shilong Zou, Dan Sun, Guozhe Ren   +4 more
doaj   +1 more source