Results 91 to 100 of about 11,847,871 (295)

Reduced antihypertensive treatment with maintained ambulatory blood pressure control following weight loss in type 2 diabetes

Background: In individuals with type 2 diabetes and hypertension, weight loss may reduce antihypertensive treatment needs, but effects on blood pressure variability and nocturnal dipping are unclear.
Brunström, Mattias, Gladzki, Lucas, Otten, Julia   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Study on simplified prediction method for pressure drop of the secondary system coolant in PWR steam generator (Consideration of evaluation model for U-Tubes area)

Nihon Kikai Gakkai ronbunshu, 2017
Improvement of Pressurized Water Reactor (PWR) thermal efficiency has strong effects on the plant economy and uranium resource economy. PWR has two main systems, the primary system including reactor and the secondary system including turbine for ...
Kohei HAMADA, Shinichi MOROOKA
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

An Experimental Investigation for Seepage-Induced Instability of Confined Broken Mudstones with Consideration of Mass Loss

Geofluids, 2017
To study and prevent water-mud-outburst disasters of tectonic fracture zones in geotechnical engineering, we tested seepage stability of confined broken mudstones with consideration of mass loss using syringe seepage method and a self-designed seepage ...
Luzhen Wang, Zhanqing Chen, Hailing Kong
doaj   +1 more source

Prediction of secondary flow losses in an entrance duct to a low-pressure turbine

Archives of Mechanics, 2019
Secondary flow features and total pressure losses by means of the total pressure loss coefficient are discussed in an entrance duct, named a turbine central frame (TCF), to a four-stage low-pressure turbine (LPT) of aero-engine.
P. Jonak, T. Borzęcki, S. Kubacki
doaj   +1 more source

Pressure Drop in Capsule Transporting Bends Carrying Spherical Capsules [PDF]

, 2012
One of the most important parameters in designing a capsule transporting pipeline is the pressure drop in the pipes carrying capsules and associated pipe fittings such as bends etc.
Ubbi, Kuldip, Asim, Taimoor, Ido, Itoro, Mishra, Rakesh   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Influence of a Periodical Fluctuation on a Profile Loss of a Cascade : Part I, Determination of the Total Pressure Loss Coefficient

Bulletin of JSME, 1984
Experiments on the total pressure loss coefficient of a cascade in a periodically fluctuating flow generated with a rotating cylinder row are described. similarity of a flow field obtained and one developing after an actual compressor rotor is examined, and the total pressure loss of a test cascade is determined from the measurement of wake profiles ...
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source