Results 81 to 90 of about 11,847,871 (295)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Implementation of empirical total pressure loss data into the DUCTFLO and TOPAZ gas transfer codes [PDF]

, 1984
Sandia presently has two computer codes capable of modeling local pressure and enthalpy losses in lines connecting gas reservoirs and receivers. Each code conserves flow continuity, momentum, and energy as a function of position along the flow path. The first of these codes, DUCTFLO, models gas flow by solving a set of coupled algebraic equations.
Winters, W.S., Kanouff, M.P.
openaire   +2 more sources

Method for Characterization of Material Loss from Modular Head-Stem Taper Surfaces of Hip Replacement Devices [PDF]

, 2015
Assessment of the head-stem taper junction requires the estimation of material loss from the taper surfaces of both femoral head and stem. This paper describes a method for the measurement and analysis of material loss from the modular taper junction of ...
Alister Hart, Hart, Alister, Radu Racasan, Liam Blunt, John Skinner, Skinner, John A., Bills, Paul, Bills, Paul J., Blunt, Liam, Skinner, John, Paul Bills, Racasan, Radu   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Numerical Analysis of Total Pressure Loss in Supersonic Nozzle Flow with Condensation

, 1987
A rapid expansion of moist air or steam in a supersonic nozzle gives rise to condensation and the total pressure of the flow is reduced by this nonequilibrium phenomenon.
松尾, 一泰, Kawagoe, Shigetoshi, Kwon, Soon Bum, Matsuo, Shigeru, 権, 純範, 川越, 茂敏, 松尾, 繁, Matsuo, Kazuyasu   +7 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Introduzione. Donatori, istituzioni e comunità

, 2021
Il saggio esamina criticamente il tema oggetto del volume collettaneo: i benefattori, le motivazioni e le strategie del dare fra Medioevo e prima Età contemporanea.
Edward, Loss, Mauro, Carboni
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Numerical study on variable area afterburner with wide bypass ratio

Xibei Gongye Daxue Xuebao
To investigate the impact of variable geometry components on the performance of afterburner, the afterburner of triangular variable connotation components was designed, and the effects of the different state points and duct ratio on the total pressure ...
Ma Yinzhang, Wang Zhiwu, Deng Yuanhao, Wang Jian   +3 more
doaj   +1 more source

A Validated CFD Methodology to Obtain the Total Pressure Loss Coefficients in Internal Compressible Flow at Junctions

Volume 2: Automotive Systems, Bioengineering and Biomedical Technology, Fluids Engineering, Maintenance Engineering and Non-Destructive Evaluation, and Nanotechnology, 2006
A global methodology has been developed and validated to obtain the total pressure loss coefficient in internal compressible flow at T-type junctions. This methodology is based on the calculation of the thermo-fluid properties extrapolated to the branch axes intersection, once the straight pipe friction losses numerically calculated have been ...
Pérez García, José, Sanmiguel Rojas, Enrique, Hernández Grau, José, Viedma Robles, Antonio   +3 more
openaire   +2 more sources