Results 71 to 80 of about 866,043 (269)

Sensitivity investigation of a subsonic cascade performance to geometric deviations based on statistical method

Engineering Applications of Computational Fluid Mechanics, 2020
This paper has established an evaluation system for the sensitivity analysis of cascade/compressor aerodynamic performance to geometric deviations. The system includes blade profile parameterization with non-uniform rational B-spline (NURBS), uniform ...
Weixiong Chen, Yangang Wang, Hanru Liu, Hao Wang, Jiawei Hu   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Numerical study on variable area afterburner with wide bypass ratio

Xibei Gongye Daxue Xuebao
To investigate the impact of variable geometry components on the performance of afterburner, the afterburner of triangular variable connotation components was designed, and the effects of the different state points and duct ratio on the total pressure ...
Ma Yinzhang, Wang Zhiwu, Deng Yuanhao, Wang Jian   +3 more
doaj   +1 more source

A Validated CFD Methodology to Obtain the Total Pressure Loss Coefficients in Internal Compressible Flow at Junctions

Volume 2: Automotive Systems, Bioengineering and Biomedical Technology, Fluids Engineering, Maintenance Engineering and Non-Destructive Evaluation, and Nanotechnology, 2006
A global methodology has been developed and validated to obtain the total pressure loss coefficient in internal compressible flow at T-type junctions. This methodology is based on the calculation of the thermo-fluid properties extrapolated to the branch axes intersection, once the straight pipe friction losses numerically calculated have been ...
Pérez García, José, Sanmiguel Rojas, Enrique, Hernández Grau, José, Viedma Robles, Antonio   +3 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Study on simplified prediction method for pressure drop of the secondary system coolant in PWR steam generator (Consideration of evaluation model for U-Tubes area)

Nihon Kikai Gakkai ronbunshu, 2017
Improvement of Pressurized Water Reactor (PWR) thermal efficiency has strong effects on the plant economy and uranium resource economy. PWR has two main systems, the primary system including reactor and the secondary system including turbine for ...
Kohei HAMADA, Shinichi MOROOKA
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An Experimental Investigation for Seepage-Induced Instability of Confined Broken Mudstones with Consideration of Mass Loss

Geofluids, 2017
To study and prevent water-mud-outburst disasters of tectonic fracture zones in geotechnical engineering, we tested seepage stability of confined broken mudstones with consideration of mass loss using syringe seepage method and a self-designed seepage ...
Luzhen Wang, Zhanqing Chen, Hailing Kong
doaj   +1 more source

Prediction of secondary flow losses in an entrance duct to a low-pressure turbine

Archives of Mechanics, 2019
Secondary flow features and total pressure losses by means of the total pressure loss coefficient are discussed in an entrance duct, named a turbine central frame (TCF), to a four-stage low-pressure turbine (LPT) of aero-engine.
P. Jonak, T. Borzęcki, S. Kubacki
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source