Results 61 to 70 of about 866,043 (269)

Experimental study of a diagonal-flow pump. Wake characteristics and total pressure loss.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B, 1986
This paper presents experimental results on the wake characteristics of a mixed-flow impeller and their relation to the impeller loss. The circumferential variations of the velocity at the impeller exit were measured at various radial locations using a five-hole pressure probe with quick response.
UNO, Mitsuo, MATSUNAGA, Shigenori, ISHINODA, Akihiko, ARIMURA, Makoto, TSUKAMOTO, Tadashi, TSUKAMOTO, Hiroshi   +5 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Aerodynamic characteristics of CMC turbine blades under diverse surface features and inlet conditions

Case Studies in Thermal Engineering
The paper investigates the aerodynamic characteristics of turbine blades with three different surface features under five attack angles and three outlet Mach numbers (Ma) through experimental and simulation approaches.
Dewei Zhang, Mingdong Zhao, Zheng Wang, Longfei Wang, Junkui Mao, Yimin Li, Xuejian Zhu   +6 more
doaj   +1 more source

Advanced Compressor Loss Correlations, Part II: Experimental Verifications

International Journal of Rotating Machinery, 1997
Reliable efficiency calculation of high-subsonic and transonic compressor stages requires a detailed and accurate prediction of the flow field within these stages.
M. T. Schobeiri
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Implementation of empirical total pressure loss data into the DUCTFLO and TOPAZ gas transfer codes [PDF]

, 1984
Sandia presently has two computer codes capable of modeling local pressure and enthalpy losses in lines connecting gas reservoirs and receivers. Each code conserves flow continuity, momentum, and energy as a function of position along the flow path. The first of these codes, DUCTFLO, models gas flow by solving a set of coupled algebraic equations.
Winters, W.S., Kanouff, M.P.
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Correlation between total pressure losses of highly loaded annular diffusers and integral stage design parameters

Journal of the Global Power and Propulsion Society, 2018
Diffusers convert kinetic flow energy into a rise in static pressure. This pressure recovery is the primary aerodynamic design objective for exhaust gas diffusers in power-generating steam and gas turbines. The total pressure loss is an equally important
Dajan Mimic, Christoph Jätz, Florian Herbst   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source