Results 181 to 190 of about 14,000 (299)

Microglia cause HIV-induced transcriptional and metabolic changes in human neural organoids. [PDF]

Commun Biol
Capendale PE, Helgers LC, Ambikan AT, Vieira de Sá R, Wolthers KC, Geijtenbeek TBH, Sridhar A, Neogi U, Pajkrt D.   +8 more
europepmc   +1 more source

Paternal Exposure to the Neonicotinoid Pesticide Clothianidin Alters Sperm MicroRNA Profiles in Mice and Intergenerationally Reduces Locomotor Activity in Male Offspring

Journal of Applied Toxicology, EarlyView.
ABSTRACT Accumulating evidence suggests that paternal environmental factors have epigenetic effects on sperm and influence offspring. Neonicotinoid pesticides (NNs), which are widely used around the world, are known to affect offspring phenotypes through maternal exposure in mice, but the effect of the paternal exposure remains unknown.
Makiko Ito, Tetsushi Hirano, Sarika Nunobiki, Ayano Yoshimoto, Yukako Hara, Yuya Ishida, Sakura Yonoichi, Youhei Mantani, Toshifumi Yokoyama, Yoshiaki Tabuchi, Yoshinori Ikenaka, Nobuhiko Hoshi   +11 more
wiley   +1 more source

ZPR1 Is Dispensable for HPV R-Loop Resolution but Regulates Host R-Loop Dynamics. [PDF]

Viruses
Moffitt R, Brooks S, Androphy EJ, DeSmet M.   +3 more
europepmc   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

The intellectual base and research fronts of LGR5: a bibliometric analysis. [PDF]

Front Res Metr Anal
Ding R, Tang Z, Xu R, Deng Z.
europepmc   +1 more source

Tannic Acid Mitigates Monosodium Glutamate‐Induced Cortical Damage by Modulating Synaptic and Calcium‐Related Gene and Protein Expression

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neurotoxicity induced by excessive glutamatergic signaling is associated with synaptic dysfunction, calcium imbalance, and oxidative stress, which are key molecular events implicated in several neurodegenerative conditions. Monosodium glutamate (MSG), a common flavor enhancer, may exert neurotoxic effects, particularly on synaptic integrity ...
Medine Sibel Karagac, Enver Fehim Koçpinar, Hamid Ceylan   +2 more
wiley   +1 more source

Towards Maintenance 5.0: Resilience-Based Maintenance in AI-Driven Sustainable and Human-Centric Industrial Systems. [PDF]

Sensors (Basel)
Bukowski L, Werbinska-Wojciechowska S.
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

A haplotype-resolved chromosome-level genome assembly of autotetraploid Chinese yam (<i>Dioscorea polystachya</i>) elucidates dioscin biosynthesis and regulation. [PDF]

Hortic Res
Shan N, Xiao Y, Li T, Wang P, Ali A, Sun J, Wang S, Zhu Q, Cao T, Luo S, Lin J, Li Z, Zhou Q, Huang Y.   +13 more
europepmc   +1 more source

Perceived Educational Value of a Self‐Developed 3D‐Printed Pediatric Dentistry Simulator

Journal of Dental Education, EarlyView.
ABSTRACT Purpose To design and assess a 3D‐printed pediatric dentistry simulator and to evaluate its perceived educational value and realism through student and expert feedback. Methods A maxillary simulator that is mountable on phantom heads was developed and produced by desktop stereolithography with single‐use inserts, enabling proximal caries ...
Michel Benyamin, Sandrella Hamdan, Timothy Fasham, Samuel Morice, Stephane Le Goff, Maria‐Antonietta D'Agostino, Marie Jannot, Yasmine Smail, Jean‐Pierre Attal, Hélène Gouze, Elisabeth Dursun, Philippe Francois   +11 more
wiley   +1 more source