Results 201 to 210 of about 14,000 (299)

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Mind and Cosmos as Throughput Systems: A Convergence Through the Throughput Model

Systems Research and Behavioral Science, EarlyView.
ABSTRACT This paper advances a conceptual and mathematical foundations approach by applying the throughput model (TPM) to cosmic phenomena, reframing the universe as an extended information processing system. TPM's four stages, Perception, Information, Judgement and Decision Choice, are reformulated in explicit information‐theoretic and dynamical ...
Waymond Rodgers
wiley   +1 more source

Multi-omic profiles of Sorghum genotypes with contrasting heat tolerance connect pathways related to thermotolerance. [PDF]

J Exp Bot
Watson-Lazowski A, Cano FJ, Kim M, Benning U, Koller F, George-Jaeggli B, Cruickshank A, Mace E, Jordan D, Pernice M, Warren C, Ghannoum O.   +11 more
europepmc   +1 more source

Creep Performance of Stainless Steel 316 Brackets: Insights From Conventional and Advanced Modeling Approaches

steel research international, EarlyView.
Creep behavior of SS 316 brackets is examined through experiments, conventional creep laws, and advanced constitutive modeling. Long‐term deformation, stress redistribution, and life prediction are compared under service‐relevant loads. The study highlights the limits of classical models and demonstrates improved accuracy using advanced approaches for ...
Mohsin Sattar, Jan Hosek, Maaz Akhtar, Uliana Finaeva, Muhammad Muzamil, Naser A. Alsaleh, Asad A. Zaidi, Barun Haldar   +7 more
wiley   +1 more source

Single-Cell Multi-Tissue T Cell Clonal Dynamics Reveal Distinct Immune Coercion Landscapes in MSI and MSS Colorectal Cancer. [PDF]

Int J Mol Sci
Zhan Q, Zhang S, Cao B, Chen L, Xie L.
europepmc   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

The impact of rumen and hindgut microbiomes on the persistent productivity of long-lived dairy cows. [PDF]

Microbiome
Yang J, Feng Y, Guo T, Guo S, Yang M, Zhou D, Lin P, Wang A, Jin Y.   +8 more
europepmc   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Multimodal profiling reveals cell type-specific pseudouridine modification and density-dependent translational regulation. [PDF]

Nucleic Acids Res
McCormick CA, Meseonznik M, Qiu Y, Fanari O, Goyal P, Thomas M, Shokoufandeh M, Liu Y, Bloch D, Greenfield C, Klink IN, Jain M, Wanunu M, Rouhanifard SH.   +13 more
europepmc   +1 more source

Effect of Unit Cell Topology on Dielectric Properties of Periodic Lattice Materials Used for Functionally Graded Insulation

High Voltage, EarlyView.
ABSTRACT Periodic lattice material (PLM) is an innovative material system capable of rapidly and efficiently constructing functionally graded materials (FGMs). Among various PLM structures, triply periodic minimal surfaces (TPMS) exhibit numerous advantages, making TPMS‐based lattice materials a potential candidate to electrical FGMs.
Zihao Liu, Wendong Li, Peng Sun, Ni Wang, Xin Zhao, Yucheng Zhang, Chao Wang, Guanjun Zhang   +7 more
wiley   +1 more source