Results 211 to 220 of about 8,406,914 (282)

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

open access: yesPhytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan   +8 more
wiley   +1 more source

Beyond Initial Adoption: How Lean Six Sigma Is Sustained, Adapted, and Used in the U.S. Textile and Apparel Industry

open access: yesQuality and Reliability Engineering International, EarlyView.
ABSTRACT This study examines how Lean Six Sigma (LSS) currently functions in the U.S. textile and apparel industry after years of adoption and use. Moving beyond isolated project‐level evidence, this study investigates whether LSS has been implemented as an organizational capability and integrated into the corporate culture, adapted to textile‐specific
Alireza Vahedi Fakhr   +2 more
wiley   +1 more source

Chronic Cortisol Exposure Reshapes Chromatin Accessibility and Gene Expression: Implications for Growth and Welfare in Rainbow Trout (<i>Oncorhynchus mykiss</i>). [PDF]

open access: yesInt J Mol Sci
Larrondo L   +8 more
europepmc   +1 more source

A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence

open access: yesSmart Molecules, EarlyView.
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen   +8 more
wiley   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

The Size, Demography, and Distribution of Cambodia's Largest Elephant Population Revealed Using Traditional Genetic Tools and a Novel SNP Panel

open access: yesIntegrative Zoology, EarlyView.
Asian elephant population parameters were assessed using microsatellite, SNP, and sex determination DNA markers. This represents one of the first studies in mainland Asia to demonstrate that integrating microsatellite and SNP data enhances genotyping success from degraded fecal samples, increases the number of useable samples and markers, and ...
Rachel Crouthers   +5 more
wiley   +1 more source

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